blood platelets abnormal in SPMS
blood platelets abnormal in SPMS
Increased level of fibrinogen chains in the proteome of blood platelets in secondary progressive multiple sclerosis patients.
https://www.ncbi.nlm.nih.gov/pubmed/30838756
Epidemiological studies indicate a high risk of stroke, heart failure and myocardial infarction in patients with multiple sclerosis, especially in its secondary progressive (SPMS) phase. Some ischaemic events are directly associated with abnormal platelet functions and their prothrombotic activity. Recent reports, including this study, confirm the increased activation of circulating platelets in SPMS, and also show increased platelet reactivity, among other responses, as well as strong aggregation.
In this current study, we conducted a comparative analysis of the platelet proteome in SPMS patients and in healthy controls, to demonstrate the quantitative and qualitative differences likely to affect functional changes observed in SPMS. During densitometry evaluation of 2-D fluorescence difference gel electrophoresis, we observed differences between the electrophoretic patterns of SPMS platelets and the control samples. To determine a detailed characterisation of the proteome changes in the SPMS patients' blood platelets, in the next stage, we performed mass spectrometry of selected spots and indicated the increased presence of four proteins (fibrinogen, α-2 macroglobulin, septin-14 and tubulin β-1 chain).
The most important of these is the increased amount of prothrombotic protein, fibrinogen, which seems to confirm the accuracy of the imaging and potentially explains the increased risk of platelet-origin thrombotic events. This study provides new knowledge of the potential existence of the molecular mechanisms responsible for the acceleration of the platelet pro-coagulant function in SPMS. This can help to identify new targets for therapy, which can then be used not only in the second stage of the disease.
Free full text.
https://onlinelibrary.wiley.com/doi/epd ... jcmm.14244
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 405 Views
-
Last post by robbie
Wed Dec 18, 2019 2:47 pm
-
- 0 Replies
- 217 Views
-
Last post by frodo
Mon May 11, 2020 3:44 am
-
-
PPMS and SPMS may be different
by frodo » Sun Aug 11, 2019 3:53 am » in MS Etiology and Pathogenesis - 0 Replies
- 915 Views
-
Last post by frodo
Sun Aug 11, 2019 3:53 am
-
-
- 7 Replies
- 1304 Views
-
Last post by Jaded
Thu Oct 10, 2019 9:24 am
-
-
Ibudilast for PPMS better than for SPMS
by frodo » Fri Jan 22, 2021 10:52 pm » in MS Etiology and Pathogenesis - 0 Replies
- 14 Views
-
Last post by frodo
Fri Jan 22, 2021 10:52 pm
-
-
-
Simvastatin trial for SPMS in UK recruiting
by frodo » Fri Mar 15, 2019 4:42 am » in General Discussion - 1 Replies
- 606 Views
-
Last post by Jaded
Wed Mar 20, 2019 9:36 am
-
-
-
lipids differentiate PPMS and SPMS
by frodo » Fri Oct 02, 2020 4:47 am » in MS Etiology and Pathogenesis - 0 Replies
- 235 Views
-
Last post by frodo
Fri Oct 02, 2020 4:47 am
-
-
-
PPMS & SPMS are qualitatively indistinguishable
by NHE » Sun Jan 03, 2021 2:38 am » in General Discussion - 3 Replies
- 147 Views
-
Last post by frodo
Thu Jan 14, 2021 9:30 pm
-
-
- 0 Replies
- 6203 Views
-
Last post by NHE
Mon Nov 25, 2019 5:46 pm