Clearance of cerebrospinal fluid from the sacral spine through lymphatic vessels
http://jem.rupress.org/content/early/20 ... 1.abstract
Abstract
The pathways of circulation and clearance of cerebrospinal fluid (CSF) in the spine have yet to be elucidated. We have recently shown with dynamic in vivo imaging that routes of outflow of CSF in mice occur along cranial nerves to extracranial lymphatic vessels. Here, we use near-infrared and magnetic resonance imaging to demonstrate the flow of CSF tracers within the spinal column and reveal the major spinal pathways for outflow to lymphatic vessels in mice. We found that after intraventricular injection, a spread of CSF tracers occurs within both the central canal and the spinal subarachnoid space toward the caudal end of the spine. Outflow of CSF tracers from the spinal subarachnoid space occurred predominantly from intravertebral regions of the sacral spine to lymphatic vessels, leading to sacral and iliac LNs. Clearance of CSF from the spine to lymphatic vessels may have significance for many conditions, including multiple sclerosis and spinal cord injury.
lymphatic vessels in the spine
Re: lymphatic vessels in the spine
Thanks for the link which is very timely for me because a back injury has impacted my sacral spine, impeding movement in general (tensed up the musculature) and no doubt CSF circulation which I believe is manifesting as MS Progression.
-
- Similar Topics
- Replies
- Views
- Last post
-
- 1 Replies
- 1243 Views
-
Last post by frodo