This Is MS Multiple Sclerosis Knowledge & Support Community

2019 Oct
T. Tucker Inc., Ottawa, Ontario, Canada
Fluid dynamics of thoracic cavity venous flow in multiple sclerosis.
https://www.ncbi.nlm.nih.gov/pubmed/31443776

Abstract
This paper hypothesizes, based on fluid dynamics principles, that in multiple sclerosis (MS) non-laminar, vortex blood flow occurs in the superior vena cava (SVC) and brachiocephalic veins (BVs), particularly at junctions with their tributary veins. The physics-based analysis demonstrates that the morphology and physical attributes of the major thoracic veins, and their tributary confluent veins, together with the attributes of the flowing blood, predict transition from laminar to non-laminar flow, primarily vortex flow, at select vein curvatures and junctions. Non-laminar, vortex flow results in the development of immobile stenotic valves and intraluminal flow obstructions, particularly in the internal jugular veins (IJVs) and in the azygos vein (AV) at their confluences with the SVC or BVs. Clinical trials' observations of vascular flow show that regions of low and reversing flow are associated with endothelial malformation. The physics-based analysis predicts the growth of intraluminal flaps and septa at segments of vein curvature and flow confluences. The analysis demonstrates positive correlations between predicted and clinically observed elongation of valve leaflets and between the predicted and observed prevalence of immobile valves at various venous flow confluences. The analysis predicts the formation of sclerotic plaques at venous junctions and curvatures, in locations that are analogous to plaques in atherosclerosis. The analysis predicts that increasing venous compliance increases the laminarity of venous flow and reduces the prevalence and severity of vein malformations and plaques, a potentially significant clinical result. An over-arching observation is that the correlations between predicted phenomena and clinically observed phenomena are sufficiently positive that the physics-based approach represents a new means for understanding the relationships between venous flow in MS and clinically observed venous malformations.

Thanks. This reminds me that in the old times of CCSVI some reports appeared speaking about venous malformations in post-mortem autopsies of MS patients. For some reason, I never hear about that anymore.

This article is so important! Thank you. Who is the author, Tucker? He’s in Canada? Super important for the many Canadians with MS.
Maybe call it Fluid Dynamics of ... Venous Flow in MS.
The thoracic cavity words might obscure the relevance it has for those of us familiar with CCSVI. And it specifically mentions internal jugular veins and azygous vein.

"Fluid dynamics of cerebrospinal venous flow..."

Here is another article by Trevor Tucker, Ph.D., also published October 2019.

"Fluid dynamics of cerebrospinal venous flow in multiple sclerosis."
PMID: 31443762 DOI: 10.1016/j.mehy.2019.109255
--See the abstract, below.

Tucker was active on this forum and at related CCSVI conferences 2011 through 2013. There are a lot of exchanges
with him on this forum (search ttucker3). He also has a 2011 paper on PubMed:

"A physics link between venous stenosis and multiple sclerosis."
Tucker TW.
Med Hypotheses. 2011 Dec;77(6):1074-8. doi: 10.1016/j.mehy.2011.09.006. Epub 2011 Sep 29.
PMID: 21958625

Dr. Zamboni cited the above paper in 2015:

"The Oscillating Component of the Internal Jugular Vein Flow: The Overlooked Element of Cerebral Circulation."
Sisini F, Toro E, Gambaccini M, Zamboni P.
Behav Neurol. 2015; 2015:170756. Epub 2015 Dec 9.
PMID: 21958625 DOI: 10.1016/j.mehy.2011.09.006

Thank you, Mr. Tucker, for these two new papers in 2019 and for all of your work.

--violin


Med Hypotheses. 2019 Oct;131:109255. doi: 10.1016/j.mehy.2019.109255. Epub 2019 Jul 2.
Fluid dynamics of cerebrospinal venous flow in multiple sclerosis.
Tucker T1.
Author information
1
T. Tucker Inc., Canada.
Abstract
Stenotic immobile valves and other malformations obstruct normal cerebrospinal venous outflow, resulting in reflux flow which combines with the normal outflow to produce standing pressure waves in the internal jugular and other cerebrospinal veins. It is hypothesized that, if the cerebrospinal venous structure between the obstruction and the deep cerebral veins is sufficiently non-compliant, the standing wave will result in bidirectional flow in the fine cerebral veins. Bidirectional flow in the fine veins, over extended periods of time, will cause disorder in the veins' endothelial morphology, and ultimately, result in the disruption of the blood-brain barrier as observed in multiple sclerosis. This physics-based analysis demonstrates a positive correlation between clinically observed MS attributes with the predicted flow patterns and venous malformations that are based on fluid dynamics principles that include venous compliance influences. The physics-based approach used in this analysis provides new insights into MS pathologies based on predicted pressure and flow patterns.

Copyright © 2019. Published by Elsevier Ltd.

PMID: 31443762 DOI: 10.1016/j.mehy.2019.109255