CSF Flow. Probably the link between veins and MS
"Several lines of evidence support the notion that regional differences in CSF flow might facilitate focal or diffuse intrathecal trapping of immune cells and stasis of inflammatory molecules, which may diffuse through the pial surface toward the inner cortical layers, in turn mediating a detrimental effect in the adjacent GM"
Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis
https://onlinelibrary.wiley.com/doi/ful ... acn3.50893
and also related:
https://www.mdedge.com/multiplesclerosi ... flammatory
https://link.springer.com/chapter/10.10 ... 26269-3_24