The perivascular space (PVS): New frontier in MS research
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions
https://academic.oup.com/brain/article/ ... 14/5836675
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been suggested that in the progressive late phase, inflammatory lesion activity declines.
These data show that in chronic progressive multiple sclerosis cases, inflammatory lesion activity and demyelinated lesion load is associated with an increased number of T cells clustering in the perivascular space. Inflammatory active multiple sclerosis lesions are populated by CD8+ tissue-resident memory T cells, which show signs of reactivation and infiltration of the brain parenchyma.
Altogether, our findings point to the PVS as a new frontier for progressive multiple sclerosis treatment development. Understanding the mechanisms that are involved in CD8+ TRM cells expanding in the PVS, entering mixed active/inactive lesions, and driving ongoing inflammatory lesion activity could provide targets for new disease-modifying therapies with efficacy in progressive multiple sclerosis