angiogenesis disturbed in MS

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frodo
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angiogenesis disturbed in MS

Post by frodo » Mon Sep 21, 2020 12:26 am

Serum Anjiogenesis Factors of Neuropilin-1 andNeuropilin-2 Levels in CIS and RRMS

https://assets.researchsquare.com/files ... dd6a14.pdf

Discussion

In the present study, we showed Neuropilin-1 and 2 are elevated in serum from CIS and RRMS compared with healthy controls. We report no correlation between age, EDSS, disease duration and treatments group at RRMS patients. This is the first study to evaluate of relationship between CIS, RRMS and serum Neuropilin 1 and 2.

Clinically Isolated Syndrome is often the first manifestation of MS. The majority of patients with CIS will go on to develop MS. Studies evaluating the effect of angiogenesis in these patients are limited. Boroujerdi et al. stated that this increase in pre-symphomatic increase in angiogenesis support spathogenic relay in the pathogenesis of MS [20]. In our study, high levels in CIS patients support this view. These results may indicate that angiogenesis may occur even in the early stages of the disease.

RRMS is the most common form of MS disease, and the disease progresses over time. Multiple sclerosis patient serum and CNS paranchyma proinflammatory cytokines were elevated, as well as the progression of MS and proinflammatory cytokines were reported in Korea. Ribatti et al. demonstrated that angiogenic activity Cerebrospinal fluid samples of patients and demonstrated angiogenesis as a key event in pathogenesis and progression.

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