CCSVI RESEARCH here

[kenneb9]

http://jrsm.rsmjournals.com/cgi/content/full/99/11/589
Zamboni
Royal Society of medicine

[mrhodes40]

I added a link to Dr B Lee's new paper on venous malformation in the replicating studies section....page one post 2 of this thread.

The big links are so numerous now it is hard to keep them organized...that seemed the best location for the new information. Any better ideas let me know.

[thisisalex]

Dear administrator,

please do update the first post with this document, becauseits a very good and detailed document about dr Haacke's knowledge:

Hi

I looked for the Haacke protocol, and a direct google search on the site (search string was: "pdf site:ms-mri.com" came up with a really great stuff. It looks like it is the detailed description of the Haacke MR protocol with detailed notes, historical connections, even about the processing of the collected data...

shortened URL

thank you
Alex

[AndrewKFletcher]

Thanks Alex.

[William57]

Hi

I looked for the Haacke protocol, and a direct google search on the site (search string was: "pdf site:ms-mri.com" came up with a really great stuff. It looks like it is the detailed description of the Haacke MR protocol with detailed notes, historical connections, even about the processing of the collected data...

shortened URL

Hi Alex, good research. However, I do not see a name of a contributor of this writing. Or so to say: what validity has this document? By what authority is this written?
It looks quite impressing, but it would have more impact if we know that someone of e.g. dr. Zamboni's or dr. Haacke's team has written this.

Do you know this by any change?

[thisisalex]

I do not see a name of a contributor of this writing. Or so to say: what validity has this document? By what authority is this written?

I dont know... i have found it only by google, it is not even linked on the site. The site is dr Haacke's, and the document is based on some other material by Dr. Haacke...

alex

[thisisalex]

I have just checked Hacke's site and it looks like there is a protocol for 1.5 Tesla also (not just for 3 Tesla)
http://www.ms-mri.com/potential.php

alex

[Sotiris]

I do not see a name of a contributor of this writing. Or so to say: what validity has this document? By what authority is this written?

I dont know... i have found it only by google, it is not even linked on the site. The site is dr Haacke's, and the document is based on some other material by Dr. Haacke...

alex

FYI. On 2 Dec 2009, Haacke's site had an article titled "MR Protocol to Evaluate the Potential CCSVI Explanation of Multiple Sclerosis". At the end of the article there was the following paragraph:

More information about the scanning procedure can be found at:
1) MR Parameters
2) Detailed Sequences Description
3) Scanning Procedure
4) Dicoms
5) IRB forms
6) Consent forms
7) Site invitation letter
8) R21 proposal on SWI and CCSVI

The only link that was working at this time, was the link of point 8, i.e. the mentioned protocol. (points 5 to 7 had no link)

[zap]

Hmm, did the paper I found get snipped on purpose or just get left out in a revision? It's not medical research, but I think it's VERY darn interesting and relevant anyway:

Social constructionism and medical sociology: a study of the vascular theory of multiple sclerosis

http://www3.interscience.wiley.com/cgi- ... 0/PDFSTART

... and from the late 80s!



(edited to fix link to full text)

[taxi]

http://www3.interscience.wiley.com/cgi- ... 1&SRETRY=0

That link doesn't work (odd cookie error) but this one seems to:

http://www3.interscience.wiley.com/jour ... 0/abstract

Cheers
Mark

[fiddler]

Folks, as reported in the posting http://www.thisisms.com/ftopicp-97519-i ... html#97519, it is good to know that Charity Intelligence Canada has, on the basis of its own analysis, recommended to institutional and private donors that CCSVI research in Canada should be a high priority target for donations since it is likely to produce tremendous social and economic dividends.

Perhaps others outside of Canada should bring this to the attention of similar organizations in their own countries, since it would bring CCSVI research to the attention of donors who might otherwise not be aware of the potential value of CCSVI research and intervention.

The Ci report itself can be found at: http://charityintelligence.ca/pdfs/Ci_C ... laimer.pdf

...Ted

[sbr487]

I dont know if anyone has seen this paper. Its more like a summary of work Dr. Z has carried out.

http://www.fondazionehilarescere.org/pdf/CX.PDF

[Rose2]

Hi. Just wondering if I post will this Bump the RESEARCH Sticky to the top of the Stickies?? It seems like the RESEARCH Sticky should hold the top slot for newcomers. just my thoughts. Rose

[eric593]

http://www.ncbi.nlm.nih.gov/sites/entre ... querykey=1

April, 2010 International Journal of Angiology, etc.

Multiple articles on CCSVI (#1-12) on Pub-Med list (at link and below)

1. Chronic cerebro-spinal venous insufficiency: report of transcranial magnetic stimulation follow-up study in a patient with multiple sclerosis.

Plasmati R, Pastorelli F, Fini N, Salvi F, Galeotti R, Zamboni P.

Int Angiol. 2010 Apr;29(2):189-92.
PMID: 20351675 [PubMed - in process]

2. Hemodynamic patterns of chronic cerebrospinal venous insufficiency in multiple sclerosis. Correlation with symptoms at onset and clinical course.

Bartolomei I, Salvi F, Galeotti R, Salviato E, Alcanterini M, Menegatti E, Mascalchi M, Zamboni P.

Int Angiol. 2010 Apr;29(2):183-8.
PMID: 20351674 [PubMed - in process]

3. Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study.

Malagoni AM, Galeotti R, Menegatti E, Manfredini F, Basaglia N, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):176-82.
PMID: 20351673 [PubMed - in process]

4.Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study.

Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):158-75.
PMID: 20351672 [PubMed - in process]

5. Iron stores and cerebral veins in MS studied by susceptibility weighted imaging.

Haacke EM, Garbern J, Miao Y, Habib C, Liu M.

Int Angiol. 2010 Apr;29(2):149-57.
PMID: 20351671 [PubMed - in process]

6. CSF dynamics and brain volume in multiple sclerosis are associated with extracranial venous flow anomalies: a pilot study.

Zamboni P, Menegatti E, Weinstock-Guttman B, Schirda C, Cox JL, Malagoni AM, Hojnacki D, Kennedy C, Carl E, Dwyer MG, Bergsland N, Galeotti R, Hussein S, Bartolomei I, Salvi F, Ramanathan M, Zivadinov R.

Int Angiol. 2010 Apr;29(2):140-8.
PMID: 20351670 [PubMed - in process]

7. Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls.

Hojnacki D, Zamboni P, Lopez-Soriano A, Galleotti R, Menegatti E, Weinstock-Guttman B, Schirda C, Magnano C, Malagoni AM, Kennedy C, Bartolomei I, Salvi F, Zivadinov R.

Int Angiol. 2010 Apr;29(2):127-39.
PMID: 20351669 [PubMed - in process]

8. The reproducibility of colour Doppler in chronic cerebrospinal venous insufficiency associated with multiple sclerosis.

Menegatti E, Genova V, Tessari M, Malagoni AM, Bartolomei I, Zuolo M, Galeotti R, Salvi F, Zamboni P.

Int Angiol. 2010 Apr;29(2):121-6.
PMID: 20351668 [PubMed - in process]

9. Internal jugular vein morphology and hemodynamics in patients with multiple sclerosis.

Al-Omari MH, Rousan LA.

Int Angiol. 2010 Apr;29(2):115-20.
PMID: 20351667 [PubMed - in process]

10. Extracranial Doppler sonographic criteria of chronic cerebrospinal venous insufficiency in the patients with multiple sclerosis.

Simka M, Kostecki J, Zaniewski M, Majewski E, Hartel M.

Int Angiol. 2010 Apr;29(2):109-14.
PMID: 20351666 [PubMed - in process]

11. Embryological background of truncular venous malformation in the extracranial venous pathways as the cause of chronic cerebro spinal venous insufficiency.

Lee AB, Laredo J, Neville R.

Int Angiol. 2010 Apr;29(2):95-108.
PMID: 20351665 [PubMed - in process]

12. Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis.

Marrie RA, Rudick R, Horwitz R, Cutter G, Tyry T, Campagnolo D, Vollmer T.

Neurology. 2010 Mar 30;74(13):1041-7.
PMID: 20350978 [PubMed - in process]

[SoberSandy]

NEUROLOGY 2010;74:1041-1047
© 2010 American Academy of Neurology
Vascular comorbidity is associated with more rapid disability progression in multiple sclerosis
R.A. Marrie, MD, PhD, R. Rudick, MD, R. Horwitz, MD, G. Cutter, PhD, T. Tyry, PhD, D. Campagnolo, MD and T. Vollmer, MD
From the Department of Medicine (R.A.M.), University of Manitoba, Winnipeg, Canada; Neurological Institute (R.R.), Cleveland Clinic, Cleveland, OH; Department of Medicine (R.H.), Stanford University, Stanford, CA; Department of Biostatistics (G.C.), University of Alabama at Birmingham; and Division of Neurology (T.T., D.C., T.V.), Barrow Neurological Institute, Phoenix, AZ.
Address correspondence and reprint requests to Dr. Ruth Ann Marrie, Health Sciences Center, GF-533, 820 Sherbrook Street, Winnipeg, MB R3A 1R9, Canada rmarrie@hsc.mb.ca .
Background: Vascular comorbidity adversely influences health outcomes in several chronic conditions. Vascular comorbidities are common in multiple sclerosis (MS), but their impact on disease severity is unknown. Vascular comorbidities may contribute to the poorly understood heterogeneity in MS disease severity. Treatment of vascular comorbidities may represent an avenue for treating MS.
Methods: A total of 8,983 patients with MS enrolled in the North American Research Committee on Multiple Sclerosis Registry participated in this cohort study. Time from symptom onset or diagnosis until ambulatory disability was compared for patients with or without vascular comorbidities to determine their impact on MS severity. Multivariable proportional hazards models were adjusted for sex, race, age at symptom onset, year of symptom onset, socioeconomic status, and region of residence.
Results: Participants reporting one or more vascular comorbidities at diagnosis had an increased risk of ambulatory disability, and risk increased with the number of vascular conditions reported (hazard ratio [HR]/condition for early gait disability 1.51; 95% confidence interval [CI] 1.41–1.61). Vascular comorbidity at any time during the disease course also increased the risk of ambulatory disability (adjusted HR for unilateral walking assistance 1.54; 95% CI 1.44–1.65). The median time between diagnosis and need for ambulatory assistance was 18.8 years in patients without and 12.8 years in patients with vascular comorbidities.
Conclusions: Vascular comorbidity, whether present at symptom onset, diagnosis, or later in the disease course, is associated with a substantially increased risk of disability progression in multiple sclerosis. The impact of treating vascular comorbidities on disease progression deserves investigation.
Abbreviations: EDSS = Expanded Disability Status Scale; HR = hazard ratio; MS = multiple sclerosis; NARCOMS = North American Research Committee on Multiple Sclerosis; PDDS = Patient Determined Disease Steps