Aspirin + omega3 can reduce inflammation?

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kw202
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Aspirin + omega3 can reduce inflammation?

Post by kw202 » Wed Dec 30, 2015 7:53 am

Hi all,

Ran across this article while poking around on MS and diet/omega-3 supplementation. It seems that there are some studies showing that low-dose aspirin combined with omega-3 supplementation can induce an additional anti-inflammatory response. I'm not the sharpest tool in the shed, and science was never my forte, so is anyone familiar with this idea or any of this research? Would love other thoughts.

I first found it referenced here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342365/

"n-3 PUFA act in synergy with aspirin on AMPK and COX enzymes but with different mechanisms. Noteworthy, in the presence of aspirin, EPA and DHA form new anti-inflammatory bioactive molecules called resolvins, protectins, and maresins, which are able to reduce cellular inflammation and inflammatory pain (Xu et al., 2010; Hong and Lu, 2013; Serhan and Chiang, 2013). This may be a relevant aspect related to the nutritional intervention in MS. Indeed, the inflammatory processes associated to MS could be also due to the low ratio omega-3 (anti-inflammatory)/omega 6 (inflammatory) PUFA and thereby to the low production of adequate amounts of resolution-inducing molecules lipoxins, resolvins, and protectins that suppress inflammation. Hence, administration of omega-3 PUFA together with aspirin or directly of lipoxins, resolvins, and protectins may form a new approach in the prevention and treatment of MS and other neuroinflammatory diseases."

Which led to here: https://www.lexi.com/individuals/dentis ... d=april-13

.. and here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331709/

.. and here: http://www.ncbi.nlm.nih.gov/pubmed/17466105

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lyndacarol
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Re: Aspirin + omega3 can reduce inflammation?

Post by lyndacarol » Wed Dec 30, 2015 10:02 am

Thank you for the link to a very good article (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342365/).

I am especially interested in the section, "Vitamin D, Vitamins A, Carotenoids, Other Vitamins, and Oligoelements."
Other compounds and elements that may be useful as supplements in MS are the vitamins D, A, E, C, B12 (Mastronardi et al., 2004), and niacin (Penberthy and Tsunoda, 2009), and oligoelements such as selenium (Boosalis, 2008) and magnesium (Galland, 2010).

Vitamin D has immune-modulatory roles and represents the most promising dietary molecule for the treatment of chronic inflammatory diseases such as MS (Smolders et al., 2008; Pierrot-Deseilligny, 2009: Cantorna, 2012; Ascherio et al., 2014).
In November your Vitamin D was tested and had results of 9.9 ng/mL. (B-12 tested low as well.) Then in your December 15 post, you reported that supplements had raised D to 33 ng/mL.

I wonder if you continue high doses of vitamin D daily, if your B-12 level is now higher, and if you notice improvements in your symptoms. I wish you all the best.

kw202
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Re: Aspirin + omega3 can reduce inflammation?

Post by kw202 » Wed Dec 30, 2015 10:18 am

lyndacarol wrote:Thank you for the link to a very good article (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342365/).

I am especially interested in the section, "Vitamin D, Vitamins A, Carotenoids, Other Vitamins, and Oligoelements."
Other compounds and elements that may be useful as supplements in MS are the vitamins D, A, E, C, B12 (Mastronardi et al., 2004), and niacin (Penberthy and Tsunoda, 2009), and oligoelements such as selenium (Boosalis, 2008) and magnesium (Galland, 2010).

Vitamin D has immune-modulatory roles and represents the most promising dietary molecule for the treatment of chronic inflammatory diseases such as MS (Smolders et al., 2008; Pierrot-Deseilligny, 2009: Cantorna, 2012; Ascherio et al., 2014).
In November your Vitamin D was tested and had results of 9.9 ng/mL. (B-12 tested low as well.) Then in your December 15 post, you reported that supplements had raised D to 33 ng/mL.

I wonder if you continue high doses of vitamin D daily, if your B-12 level is now higher, and if you notice improvements in your symptoms. I wish you all the best.
I found that section interesting too, as well as the one on supplementation. There is much to research in here.

As for me, thanks for asking! I haven't had my levels checked since that last test, but I have continued aggressive supplementation with both B12 and D3. (And have added in 90mg/day of K2, after seeing your post.)

After I got my results from the D test, where it had been boosted from 9.9 ng/ml - 33 ng/ml, I read a post from jimmylegs saying hospital staff had told her that for a quick 50-point D boost, the hospital does a course of 50,000 IU for 10 days. So that's what I did, following on my last test result.

The 10 days was done just a few days ago and now I've dropped back to 10,000 IU/day. If successful, that would have potentially raised my levels to around 80 ng/ml -- of course that's a big if, given my size. But if so, I'll probably just stay at 10k IU/day until my March retest and see where I am. Jelinek, whose plan I'm following, recommends a maintenance D dose of 5000 IU per 50kg that you weigh. (At present I weigh 140kg, so that'd be a daily dose of quite a lot more than 10k IU....)

At this time I'm not anticipating another bloodwork test until March, unless the MS specialist is also alarmed by my dosing regimen and orders one too when I see her next week :-D (first time visit - nervous).

I have had a dramatic improvement in my numb/heavy legs/feet symptoms over this same time period, however I mostly attribute that to a course of oral methylprednisolone that my neurologist put me on that spanned roughly the same timeframe. (Though, now that course is done and my lower extremity symptoms are creeping back up again, so it looks like on to IV solumedrol I go.)
Last edited by kw202 on Thu Dec 31, 2015 12:15 pm, edited 1 time in total.

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jimmylegs
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Re: Aspirin + omega3 can reduce inflammation?

Post by jimmylegs » Thu Dec 31, 2015 8:09 pm

clarification. in 2006 the hospital said take 50K IU per day for 10 days to boost 50 nmol/L. that's 20 ng/ml.

the first of two times i did something like this, it actually boosted my levels more like 70 nmol/l (28 ng/ml).

the unintended consequences of prolonged d3 high dosing (~4000 IU per day normally, over a number of years) were brutal, and at their worst had me expecting to be found dead.

even after i learned from the pharmacist that magnesium depletion was the problem (i had taken mag all along, just not enough; taking it began to reverse the worst of my issues within 2 days), it took me another few quite unpleasant years to first rebuild my tissue stores, and then properly transition my diet, and find a form and dose of magnesium supplement that would work best for me.

for years, whenever i took magnesium i would be physically able to feel it kick in. it was years again before i could go a day without a magnesium supplement, and not feel the consequences right away.

in 2009, after a serum d3 test result near 100 nmol/L, i decided on a second short term d3 megadose trial and took 50 K IU per day for just 8 days.

this time my serum d3 levels shot up by 170 nmol/L (close to 70 ng/ml), to over 270 nmol/L (~110 ng/ml). i certainly had not expected that, but had worked hard on nutritional status across the board in the intervening time and chalked it up to better absorption due to presence of needed cofactors. at the time i had most recently identified and correct a previous underlying zinc deficiency, so initially gave more credit to zinc repletion for the huge change in d3 dose response. looking back, of course there would be more to it than just one thing.

so, that second round was in 2009, and i haven't done a megadose, or felt like my levels warranted it, since. i actually haven't even had bloodwork done in ages, but have a requisition in the car and will actually have the time to go and get the labs done in january.

i've been able to physically feel the benefits of many supplements over the last decade, starting of course with b12, which was at its worst for me (undetectable) when i started measuring properly (ie with a washout) in 2006. i've physically felt benefits from iron, magnesium, b 12, zinc, and even gingko biloba, to name a few. never over the last decade have i ever felt any physical improvement as a direct result of taking vit d3, just negative side effects from doing it without proper mineral balancing.
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

kw202
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Re: Aspirin + omega3 can reduce inflammation?

Post by kw202 » Mon Jan 04, 2016 6:48 am

Thank you so much for this!! I'll digest it more later today. Have my first appointment with MS specialist this afternoon, wish me luck.

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jimmylegs
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Re: Aspirin + omega3 can reduce inflammation?

Post by jimmylegs » Mon Jan 04, 2016 3:08 pm

hope the appointment went smoothly :)
take control of your own health
pursue optimal self care at least as actively as a diagnosis
ask for referrals to preventive health care specialists eg dietitians
don't let suboptimal self care muddy any underlying diagnostic picture!

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