Ampyra, 4-AP, 4-AP-3-MeOH
It's my first post here, I have only recently discovered this site, and I have to say, it is a Godsend. I’ve been reading through the posts and I thought I’d make my own,
I have been suffering spasticity for five years now and it was only last three years that I made any progress in treating it.
Ampyra was far too expensive, in my opinion, and the amount that my insurance begrudgingly would pay for, the daily doses quite frankly did next to nothing to help my mobility.
So, then I turned to Google and discovered compounded 4-AP.
I got a prescription from my doctor (even though he'd never heard of it). I couldn't get insurance to pay for it, but it is cheap enough, so I paid 100%.
I had never even heard of a compounding pharmacy, I picked one and ordered some capsules.
Here's what I think:
Instant release 4-AP
Comes on quick. I like that. Empty stomach, and I am up and moving within 20 minutes.
Extended release 4-AP
Never works. Not if you ask me. Takes longer to kick in, then it comes on all at once like instant release.
Both instant and Extended release 4-AP
I have really noticed, after buying from numerous pharmacies, that, depending on the compounding, the effects are different. Or maybe it's the care and attention they put into the whole process, or the filler used. I don't know, but different pharmacies, different effects. I have even done side-by-side comparisons with different pharmacy's 4-APs and I stand by this.
I like 4-AP, it works very well, and it allows me to do a lot of things. Walking, obviously. Wiggle my toes. Helps my constipation. Eases my neuropathy, and pain (to a certain extent).
I wouldn't go back to Ampyra, even if it was the same price as 4-AP. It would be nice to take one pill twice per day, but I don't think it really works that way. Not for me, anyway. I am happy to take multiple 4-AP doses, as and when. Works, works quick, and on demand. And if I am inactive for a period, I can take a rest from the 4-AP.
I discovered 4-AP-3-MeOH early this year and I have been taking it ever since. Though, it is expensive, so when I run out, I return to 4-AP. I discovered it after googling around for spasticity medications, I read about it on forums for spasticity caused by other diseases. It doesn’t surprise me that there are numerous posts about 4-AP-3-MeOH here. I am, actually surprised that there aren’t more posts.
I am not sure if links are allowed here, I’ll wait to see if there are any replies saying yes or no, but I read on other forums and I Googled scientific reports about 4-AP-3-MeOH and I bought some capsules.
I didn’t really know what to expect, because all I really knew was 4-AP and Ampyra, but I was very impressed with the effects of 4-AP-3-MeOH. I’ll try and describe.
On 4-AP, I can only walk quick, and people better get out of my way, because it has to be quick, and it has to be in a straight line. And my walking is highly robotic.
On 4-AP-3-MeOH.I have so much more control. I can walk slow, I can stroll. I can stop and balance, pivot on one foot and do a sharp 90 degrees. I can even stand on one leg (for a short time).
On 4-AP, My balance is just as bad as without it. 4-AP only excels if I am walking at a rapid clip.
On 4-AP-3-MeOH.My balance is fantastic. I can close my eyes and not fall over. I can board a busy subway train and carefully manoevre my way to a space. Like I said, I can stand on one leg (short time). I tried some standing yoga poses, still fall over, but I can do a lot better than on 4-AP.
On 4-AP,I can feel something like a someone touching the sole of my foot (which I couldn’t otherwise feel, my feet feel dead.).
My fingertips usually feel dead, like covered in extremely thick skin. With 4-AP, I can actually feel through my fingertips, like if I push my thumbnails into my fingertips, I can feel the nails digging it.
On 4-AP-3-MeOH,it is completely different. I can feel the lightest sensations. Like someone touching the sole of my foot with the head of a pin, or stroke with a feather.
Maybe that’s why it helps balance so well. Signals going back and forth, reacting either way.
With 4-AP-3-MeOH, it is like I have no problem with my fingers at all. I can move my normally stiff fingers in a much more fluid manner, and my fingertips feel perfectly OK, no numbness whatsoever.
4-AP helps, 4-AP-3-MeOH not so much.
I’d say they are about the same.
Overall physical effects.
Without a doubt, the 4-AP-3-MeOH is so much more comfortable to take than the 4-AP. Almost unnoticable. The 4-AP can feel brutal at times, especially on an empty stomach. 4-AP-3-MeOH feels, I don’t know, smooth, gentle. Maybe it’s the lower dose, maybe because it’s a different chemical, maybe both.
I’ve gone on enough now. But I’d like very much to talk with anyone who has successfully treated their spasticity. I’d especially like to know if anyone else takes/has taken 4-AP-3-MeOH and what your experiences were.
I’ll talk to you all soon.