The biotin trial results are out

[Sharon]

Jimpsull, I seriously doubt there could be a patent infringement. Pharmaceutical grade Biotin is not a new compound.
What can be patented in the world of natural ingredients?
http://www.nutraingredients-usa.com/Reg ... =copyright

I would be more concerned about consuming all the fillers in the OTC Biotin in order to get to the high dosages used by MedDay. In my opinion, a reliable compounding pharmacy is the safer choice.

Sharon

[Jimpsull]

I agree with you in principal - though Med-Day has been granted a patent for use of 50 - 700 mg d-biotin for treatment of MS or stroke.

[Sharon]

Yes, Jimpsull - but they are going for an FDA approval of a drug so it can be paid for by insurance. It is not going to take pharmaceutical grade Biotin off the supplement market
An example is Klor-Con ( potassium chloride) is just a timed release tablet in a higher dosage than OTC supplement.It is still potassium chloride and you still can get it at a compounding pharmacy or at your local drug store but not in a timed release tablet. 4AP is another example ---same dosage as Ampyra but Ampyra is timed release. Skips pharmacy continues to sell 4AP but he cannot sell a timed release tablet.
Just my thoughts...
Sharon

[Sharon]

Skip Lenz (Skips Pharmacy in Florida) a reliable compounding pharmacy used by many MSers for their LDN has just posted that he has sourced a supplier for the same Biotin used in the trial. He is getting a shipment in which he will assay test. Skip will be reporting back once he finishes his testing ... stay tuned
Sharon

[Sharon]

Cerebrospinal fluid levels of biotin in various neurological disorders

A study abstract from 1999 showing low levels of Biotin in the csf of people with MS.

http://www.ncbi.nlm.nih.gov/pubmed/10577274

[CureOrBust]

Has anyone read the full study or knows anything specific which says the biotin in the trial was "slow release"? just being a devils advocate, but the biotin dose may be effective only as a single high dose.

[Sharon]

Hi Cure,
The dosage in the Phase lll trial was a range of 100mg - 300 mg per day. Tablets were 100 mg. They were not time released. Biotin used was pharmaceutical grade which is not found in most OTC low dose Biotin. We should know a little more when MedDay reports in June at the European Academy of Neurology during one of the oral sessions.

[Sharon]

Oh, and full study has not been published for the Phase all only for the small 23 patient pilot study

[ElliotB]

Biotin is biotin. Pharmaceutical grade simply means the supplement must contain in excess of 99% of the ingredient stated. So the OTC Biotin has fillers which can vary from company to company. But OTC Biotin can probably be used to get the desired dosage by taking multiple pills. I have found one brand, NATROL, that seems to have less 'fillers' than many of the other brands.

I had posted this link in one of the other Biotin threads. This company seems to be a good source for bulk pharmaceutical grade Biotin:

http://purebulk.com/biotin-pure/

[Jimpsull]

I have settled on natures bounty. Key for me:

- "as d-biotin@ on the label
- doesn't contain calcium (20 - 40 x 66 - 220 mg is too much)
- $50 per month at 200 mg per day

http://enhancedbiotintrial.blogspot.com ... s.html?m=1

[CureOrBust]

I have settled on natures bounty. Key for me:

- "as d-biotin@ on the label
- doesn't contain calcium (20 - 40 x 66 - 220 mg is too much)
- $50 per month at 200 mg per day

I purchased a few packs of these, before I started to encapsulate my own; still have a few unopened. It did worry me that they had "Titanium Dioxide" which has murmurs of being a possible carcinogenic. 220mg of calcium is nothing, most calcium supplements contain 600mg+?

I have done home made capsules before and had all the stuff apart from the Biotin itself. Not having to swallow 30 capsules a day is a relief.

[Quest56]

I have done home made capsules before and had all the stuff apart from the Biotin itself. Not having to swallow 30 capsules a day is a relief.

When buying the biotin powder in bulk, why the need to put the biotin into capsules? After measuring out a dose, couldn't the biotin powder just be dissolved in water and swallowed, or sprinkled on food and eaten?

[ElliotB]

I had put this list of ingredients together doing research on the various OTC Biotin supplements. I found only one that offer pharmaceutical grade Biotin, EU Natural Biotin 5000 mcg, 120 Vegetarian Capsules. If you come across any others, please let me know. It is a little more expensive than some of the others, $20 for 120 5000mcg capsules but it is pure Biotin:


21st Centruy

Calcium Carbonate, Cellulose, Stearic Acid, Croscarmellose Sodium, Silicon Dioxide, Magnesium Stearate


Best Naturals

Cellulose, stearic acis, silica, magnesium stearate, methylcellulose, celulose gum, glycerent


BioPower

Gelatin, Rice Powder


Country Life

Cellulose (capsule shell), cellulose, medium chain triglycerides, silica


Doctor’s Best

Dicalcium phosphate, modified cellulose (vegeterian capsule). magnesium stearate (vegetabel source), silicon dioxide



Eu Natural (pharmaceutical grade)

Vegetable capsule (no fillers)



Future Biotics

Microcrystalline cellulose, modified cellulose (vegetarian capsule), magnesium stearate, silica



Finest Nutrition
Diacalcium Phosphate , Calcium Carbonate , Gelatin , Silica , Magnesium Stearate



GLS Nutrition

Gelatin, Rice Powder


Healthy Origins

Rice flour, vegetable capsule (cellulose, water).



Linden’s Apothocary

Dicalcium Phosphate, cellulose, d-biotin, magnesium searate (v), silica


Natrol

Cellulose, Stearic Acis, Silica, Magnesium Searate, Methylcellulose, Dellose Gum, Glycerin


Nature’s Bounty

Soybean oil, gelatin, glycerin, yellow beeswax, titanium dioxide, color



Nature Made

Soybean Oil, gelatin, glycerin, yellow beeswax, water, soy lecithin, colors added



NOW Foods

Rice flower, cellulose, magnesium,stearate (vegetable source), Silica


Number One Nutrition

Rice powder, microcrystalline cellulose, hydroxpropyl methlcellulose, vegetable magnesium stearate and silicone dioxide



OmegaBoost

Geatin, Silica, Vegetable Magnesium Stearate


Oxford Vitality

Microcrystaline Cellulose, Magnesium Stearate, di-calcium phosphate



Piping rock

Rice Powder, Gelatin Capsule, Vegetable Magnesium Stearate.




Puritan’s Pride

Soybean Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Titanium Dioxide



Renevitrol Nutrition USA

Gelatin, Rice Powder.


Soligar

Microcystalline cellulose, vegetable cellulose, vegetable magnesium, stearate, silica



Sports Research

GMO free modified cornstarch, vegetable glycerin, GMO free sorbitol, carrageenan, purified water, extra virgin organic coconut oil. organic yellow beeswax


Swanson Time Release

Calcium carbonate, stearic acid, hydroxypropyl methylcellulose, food glaze, acacia, maltodextrin, may contain one or both of the following: magnesium stearate, silica.


TN (Trusted Nutrients)

soybean Oil, Geletan, vegetable glycerin, yellow beeswax, titanium dioxide color, (Shell gelatan, vegetable glycerin, titanium dioxide, color, purified water)



Vitabud

Rice Powder, Microcystalline cellulose, hydroxpropyl methylcellulose, vegetable magnesium searate and silicon dioxide



Vitamins Because

Gelatin, Rice Powder

[Sharon]

A few updates on Biotin:

Skip's Pharmacy - Florida is now shipping Biotin in 100 mg capsules http://www.skipspharmacy.com/

MedDay has shared the supplier they used in the trial (MD1003=Biotin). As noted you may contact the supplier directly.
https://scontent-lax1-1.xx.fbcdn.net/hp ... e=56015BAE

Cure -- have you noticed any changes since starting the Biotin?

Sharon

[ElliotB]

Sharon, do you have any pricing info from Skip's?