High dose biotin causes lab test interference

Biotin is an emerging therapy for the treatment of secondary progressive MS.
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High dose biotin causes lab test interference

Post by NHE » Thu Sep 26, 2019 2:41 am

If you're taking high-dose biotin then you need to be aware that it will interfere with many medical tests that rely upon biotin/streptavidin immunoassays. This could potentially lead doctors to make incorrect conclusions regarding your health, that in many cases could be critical, e.g. the presence or absence of cancer.

Here is a list presented by Medday of tests which can be distorted by high dose biotin. Note that this list is non-exhaustive and there could be other tests which are not listed, but are still sensitive to biotin interference.


Biotin can lead to false low results in sandwich immunoassays.


Biotin can lead to false high results in competitive binding immunoassays.


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