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Ocrevus is a Wonder Drug for MS

Posted: Wed Jan 31, 2018 6:15 pm
by seeva
HI Friends please read a news today1st of feb SMH newspaper news
http://www.smh.com.au/federal-politics/ ... 4yz4v.html
regards
seeva

Re: Ocrevus is a Wonder Drug for MS

Posted: Fri Apr 13, 2018 4:20 pm
by dansmail26
but is it any better then rituximab? My doc wants me to go on rituximab and keep taking avonex as the insurance company wuill keep paying for both.

Re: Ocrevus is a Wonder Drug for MS

Posted: Sat Apr 14, 2018 8:26 am
by ElliotB
per the article:

"....A few months later she is "99 per cent back to normal"

Isn't that the case for most with RRMS whether they take drugs of any kind or not? How do they know with certainty it was the Ocrevus?

Re: Ocrevus is a Wonder Drug for MS

Posted: Sun Apr 15, 2018 12:21 am
by NHE
ElliotB wrote:per the article:

"....A few months later she is "99 per cent back to normal"

Isn't that the case for most with RRMS whether they take drugs of any kind or not? How do they know with certainty it was the Ocrevus?
N's of one may or may not be interesting, but they're certainly meaningless statistically.

Re: Ocrevus is a Wonder Drug for MS

Posted: Wed Apr 25, 2018 2:06 pm
by undisclosED
If anyone is interested, there is a new, closed Facebook group that was started on April 13, 2018 specifically for PPMS, SPMS and Ocrevus.

https://www.facebook.com/groups/152024362299714/

Re: Ocrevus is a Wonder Drug for MS

Posted: Wed Oct 31, 2018 4:16 am
by Kheuer
Based on all the continually emerging data, I agree, wonder drug. First infusions 1 month post diagnosis.

New results from clinical studies show ocrevus results in some patients

RECOVERING LOST FUNCTION

Re: Ocrevus is a Wonder Drug for MS

Posted: Wed Nov 21, 2018 5:31 pm
by Kheuer
dansmail26 wrote:but is it any better then rituximab? My doc wants me to go on rituximab and keep taking avonex as the insurance company wuill keep paying for both.
Short answer = yes

Long answer =

1. It is 100% human versus the human/mouse chimeric rituxan

2. It has a higher binding affinity for CD20 expressing b cells than rituxan, and a lower affinity for non CD20 b cells --> binds more preferentially to the bad B cells than rituxan, and less to the non bad B cells

4. It has a higher efficacy at causing cell death than rituxan, it binds at different epitopes on the cell causing more efficient cell death

5. It has been clinically shown to STOP progression in some patients after 2 years of infusions.

6. It has been clinically proven to actually help some patients RECOVER LOST COGNITIVE AND PHYSICAL FUNCTION after 4 years.

It is the ONLY THERAPY to ever do #5 and #6

Re: Ocrevus is a Wonder Drug for MS

Posted: Thu Nov 22, 2018 8:28 am
by ElliotB
"It is the ONLY THERAPY to ever do #5 and #6"

Not true - there are now other safe therapies doing #5 and #6.

Re: Ocrevus is a Wonder Drug for MS

Posted: Wed Jan 09, 2019 8:44 am
by Kheuer
ElliotB wrote:
Thu Nov 22, 2018 8:28 am
"It is the ONLY THERAPY to ever do #5 and #6"

Not true - there are now other safe therapies doing #5 and #6.
Which clinically documented? Because you're statement is factually incorrect.

Ocrevus is the ONLY treatment to stop progression and also recover LOST function, unless you are talking the Klenner Protocol, which I believe to be effective, yet was not clinically documented.

I use a modified oral Klenner Protocol as adjuvant to Ocrevus.

If you did the full Klenner Protocol -- including the IM and IV doses, the cost approaches 50k+. The compounding RX for shots and IV is expensive.

The Wahl protocol has no clinical evidence to date.

FYI Genentech puts your entire out if pocket Ocrevus plus infusion clinic cost onto a debit card that YOU pay your DR with. It is essentially free and also wipes out your out of pocket max, so all your other medical care is free for the year if you get an infusion early. I'm sitting in a recliner 2 hours into my 6 hour ride right now.

Re: Ocrevus is a Wonder Drug for MS

Posted: Wed Jan 09, 2019 1:55 pm
by ElliotB
"5. It has been clinically shown to STOP progression in some patients after 2 years of infusions."

in some patients?

FACT: The progression in some patients stops without any intervention of any kind. This is the case for the majority of those with MS.


Clinical trials are easy to add bias, all too easy to manipulate, to get a desired outcome. And of course interpretation of the results can also be manipulated/biased depending on what the desired conclusion is.


Copaxone is thought to reduce the rate of relapses and to slow the progression of MS as well and there have been many clinical trials on that drug.

And of course there are numerous non-'proven' protocols.


The true fact is there is no way of knowing that any of these drugs and protocols really work. How can you really know for sure with a disease that by its nature goes into remission for most and is totally unpredictable.