IMPORTANT: New type of MS discovered. Myelocortical MS.

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IMPORTANT: New type of MS discovered. Myelocortical MS.

Post by frodo » Thu Aug 23, 2018 5:03 am

Researchers discover new subtype of multiple sclerosis (The Lancet)

https://www.ms-uk.org/researchers-disco ... -sclerosis

Cleveland Clinic researchers have discovered a new subtype of multiple sclerosis (MS), providing a better understanding of the individualised nature of the disease.

MS has long been characterised as a disease of the brain's white matter, where immune cells destroy myelin - the fatty protective covering on nerve cells. The destruction of myelin (called demyelination) was believed to be responsible for nerve cell (neuron) death that leads to irreversible disability in patients with MS.

However, in the new findings, a research team led by Bruce Trapp, Ph.D., identified for the first time a subtype of the disease that features neuronal loss but no demyelination of the brain's white matter. The findings, published in Lancet Neurology, could potentially lead to more personalised diagnosis and treatments.

This new subtype of MS, called myelocortical MS (MCMS), was indistinguishable from traditional MS on MRI. The researchers observed that in MCMS, part of the neurons become swollen and look like typical MS lesions indicative of white matter myelin loss on MRI. The disease was only diagnosed in post-mortem tissues.

The team's findings support the concept that neurodegeneration and demyelination can occur independently in MS and underscore the need for more sensitive MRI imaging techniques for evaluating brain pathology in real time and monitoring treatment response in patients with the disease.

“This study opens up a new arena in MS research. It is the first to provide pathological evidence that neuronal degeneration can occur without white matter myelin loss in the brains of patients with the disease,” said Trapp, chair of Cleveland Clinic's Lerner Research Institute Department of Neurosciences. “This information highlights the need for combination therapies to stop disability progression in MS.”

In the study of brain tissue from 100 MS patients who donated their brains after death, the researchers observed that 12 brains did not have white matter demyelination. They compared microscopic tissue characteristics from the brains and spinal cords of 12 MCMS patients, 12 traditional MS patients and also individuals without neurological disease. Although both MCMS and traditional MS patients had typical MS lesions in the spinal cord and cerebral cortex, only the latter group had MS lesions in the brain white matter.

Despite having no typical MS lesions in the white matter, MCMS brains did have reduced neuronal density and cortical thickness, which are hallmarks of brain degeneration also observed in traditional MS. Contrary to previous belief, these observations show that neuronal loss can occur independently of white matter demyelination.

“The importance of this research is two-fold. The identification of this new MS subtype highlights the need to develop more sensitive strategies for properly diagnosing and understanding the pathology of MCMS,” said Daniel Ontaneda, M.D., clinical director of the brain donation program at Cleveland Clinic's Mellen Center for Treatment and Research in MS. “We are hopeful these findings will lead to new tailored treatment strategies for patients living with different forms of MS.”
Last edited by frodo on Mon Jan 28, 2019 7:40 am, edited 4 times in total.

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Re: Thanks to MS-UK: New type of MS discovered

Post by frodo » Sat Aug 25, 2018 6:51 pm

These are big news. First of all, because 12% of patients have damage in the WM without demyelination. So much for the autoimmune demyelination theories.

In this review (https://reliawire.com/myelocortical-ms/) they explain it: "The researchers observed that in MCMS, part of the neurons become swollen and look like typical MS lesions indicative of white matter myelin loss on MRI".

Only two days after publication there are already several reactions to the article:
By the way, this is not the first time they report it. They found it in 2013.

http://onlinelibrary.ectrims-congress.e ... tiple.html

This has enormous consequences for pathogenesis theories. In 2016 a review said: "Furthermore, this study supports the concept that MS may be a neurodegenerative disease with a secondary aberrant immune response"

https://etd.ohiolink.edu/pg_10?0::NO:10 ... BID:114418

It is also interesting an interview with Bruce Trapp, leader of the team who found it.

https://www.neurologylive.com/clinical- ... -sclerosis
Last edited by frodo on Mon Aug 27, 2018 11:34 pm, edited 2 times in total.

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Re: IMPORTANT: New type of MS discovered.

Post by NHE » Sun Aug 26, 2018 3:25 am

Thanks. New paradigms are finally replacing outdated modes of thinking.

I've added MCMS to the Forums FAQ list of acronyms.
http://www.thisisms.com/forum/site-supp ... ml#p210825

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Re: Thanks to MS-UK: New type of MS discovered

Post by Kheuer » Wed Jan 09, 2019 9:11 am

frodo wrote:
Sat Aug 25, 2018 6:51 pm
These are big news. First of all, because 12% of patients have damage in the WM without demyelination. So much for the autoimmune demyelination theories.
Your statement is not scientifically supportable.

This subset of patients may be able to re-myelinate white matter more efficiently.

And AI demyelination has been proven to be a causative agent in MS.

From your link

"Although both MCMS and traditional MS patients had typical MS lesions in the spinal cord and cerebral cortex, only the latter group had MS lesions in the brain white matter."

Both the Cerebral Cortex AND Spinal Cord have myelin sheathing, and the MCMS persons showed lesions on the spinal cord and in the cerebral cortex so they had demyelination just not in the white matter.

Perhaps you should research the scientific correctness of statements that you make before you post things on the board.

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Re: IMPORTANT: New type of MS discovered.

Post by frodo » Sat Jan 12, 2019 9:33 am

Perhaps you should research the scientific correctness of statements that you make before you post things on the board.
That statement is not mine. I was just quoting the source I gave:

https://reliawire.com/myelocortical-ms/

I will quote it completely:

"In the study of brain tissue from 100 MS patients who donated their brains after death, the researchers observed that 12 brains did not have white matter demyelination. They compared microscopic tissue characteristics from the brains and spinal cords of 12 MCMS patients, 12 traditional MS patients and also individuals without neurological disease"

The sentence "so much for the autoimmune demyelination theories" is mine and I could be wrong. Anyway I was referring to an "only autoimmune" model. Sorry if that was inacurate.

Thanks for your comment anyway.

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