meningeal inflammation in early multiple sclerosis

[frodo]

Whatever MS is, meningeal inflammation (and therefore gray matter damage) is present since the beginning.

Source:
http://journals.sagepub.com/doi/abs/10. ... 8516683267

Results:

A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.
Conclusion:

This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

[SeanReynolds]

If CPn is the cause, it's pretty vital to get underway with abx therapy at once. Esp macrolides, roxithromycin seems the most effective.

Note Cpn is associated with causing uveitis, and uveitis occurs at the same time with MS.

[Scott1]

Hi,
It may be too selective to just focus on meninges. They are just a part of a broader group of connective tissue called fascia. Varieties of fascia are everywhere throughout our bodies.
It is rare for the full force of muscles to be directly applied by tendons to the skeleton. A very large proportion of that force is directed to the fascial sheets so that regions of the body that may be several joints away can be either synergistically or antagonistically involved in movement.
If the meninges are affected then why not other fascia? We are prone to stiffness and tight fascia will be involved. Dry needling the tight fascia in the body, massage and heat packs can all ease the tightness in the body.

I think article you have looked at is really talking about the pia mater which is the soft inner layer of the dural membrane system. Its made of a thin layer elastic of connective tissue. Vessels pass from it into the brain. It also forms the choroid plexus which is the arrangement of vessels that produce CSF. Dealing with that would obviously be all about treating the causes on inflammation.
Regards,