specific auto-antibodies in blood

[frodo]

Researchers have found different auto-antibodies markers in blood in SPMS and RRMS. These different biomarkers could shed light into the pathogenesis.

Autoantibodies as diagnostic biomarkers for the detection and subtyping of multiple sclerosis
http://www.jni-journal.com/article/S0165-5728(17%2930140-6/fulltext

"The top 50 most differentially expressed autoantibody biomarkers in each MS subtype compared to the other were selected and verified as significant using the methods described above. Using RRMS-specific biomarkers and the RF logic derived from the Training Set, RRMS sera were readily distinguished from SPMS sera with an overall accuracy of 100% in both Training and Testing Set comparisons."

[ThisIsMA]

Great find! At the end where they disclose their affiliations it sounds like they are applying for patents to turn this into a test that could be used to diagnose MS and to determine the transition from RRMS to SPMS. I hope they also look for PPMS biomarkers.

Its interesting that they chose depleted autoantibodies as their biomarkers. I am guessing (though I don't know) that this may mean they're looking for the absence of certain autoantibodies. Also I thought it was really interesting that they say healthy people have thousands of autoantibodies floating in there blood normally.

Lastly its really interesting that although they could tell the difference between healthy controls and people with MS with great accuracy, they couldn't tell the difference between people with MS and people with early stage Parkinsons disease...

What a mystery MS is.

Thanks for sharing the study link.

M.A.

[frodo]

More about blood tests. Morphogenetic proteins are required to grow stem cells into their final form, in this case, neurons and oligodendrocytes.

High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis.

https://www.ncbi.nlm.nih.gov/pubmed/28778435

Abstract

Blockage of bone morphogenetic protein (BMP) signaling is required for differentiation of neurons and oligodendrocytes from neural stem cells (NSCs). Sera of untreated relapsing-remitting multiple sclerosis (RR-MS) patients expressed significantly higher levels of BMP-2 compared to sera of healthy controls. BMP-2 levels correlated with BMP-4 and -5 levels only in sera of untreated MS patients. Furthermore, sera of untreated patients inhibited the neuronal differentiation of RA-treated P19 cells, which was associated with induction of phospho-SMAD signaling pathway. These results suggest that BMP-2 sera levels may play a role in the failure of remyelination and neuro-regeneration in RR-MS.

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And other interesting result. Anoctamin-2 in MS. Several reports:

*2015 - https://www.longdom.org/proceedings/neu ... 29160.html
* 2016 - https://www.ncbi.nlm.nih.gov/pubmed/26862169
* 2019 - https://www.ncbi.nlm.nih.gov/pubmed/31375628