Cross-talk between human glial cells and B cells

[frodo]

Cross-talk between human glial cells and B cells help propagation of CNS-compartmentalized in progressive MS
http://www.thisisms.com/forum/posting.p ... =post&f=59

• Astrocytes supported MS B cell survival (including CD27+ B cells)
  M2c-polarized human microglia appeared cytotoxic to B cells. Activated astrocytes increased CD86 expression on B cell surface.
  Similar results are obtained when B cells were exposed to M1-polarized microglia.
  B cells previously exposed to activated astrocytes increased T cell proliferation.
  Beff (pro-inflammatory effector B cells) down-regulate IL-10 production by microglia/macrophage, and substantially enhance pro-inflammatory cytokines (IL-12, TNF & IL-6)

These results indicate a potential bi-directional interaction between disease-relevant human B cell subsets and astrocytes CNS resident microglia and infiltrating myeloid cells, which may influence the propagation of MS-CNS compartmentalized inflammation associated with disease progression.