http://www.thisisms.com/forum/posting.p ... =post&f=59
- Astrocytes supported MS B cell survival (including CD27+ B cells)
M2c-polarized human microglia appeared cytotoxic to B cells. Activated astrocytes increased CD86 expression on B cell surface.
Similar results are obtained when B cells were exposed to M1-polarized microglia.
B cells previously exposed to activated astrocytes increased T cell proliferation.
Beff (pro-inflammatory effector B cells) down-regulate IL-10 production by microglia/macrophage, and substantially enhance pro-inflammatory cytokines (IL-12, TNF & IL-6)