First it was Neuromyelitis Optica. It was set appart from MS when anti-AQP4 antibodies were found to be specific of this kind of disease.
Then it came "anti-MOG associated encephalomyelitis". It was found that only very atypical MS could present anti-MOG antibodies, and now it is considered a separate disease.
And it has happened again. Around 2% of MS patients have auto-antibodies against a specific protein named flotillin. It seems that anti-flotilin patients will make a new different group.
https://jneuroinflammation.biomedcentra ... 017-0900-z
NOTE: Before publshing the article, it seems that they presented a "poster" in Neurology April 18, 2017 vol. 88 no. 16 Supplement P1.393, available at
http://www.neurology.org/content/88/16_ ... .393.short
Update
It seems that anyway MOGAD and MS are not mutually exclusive and can overlap
Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G in the CSF
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554713/
Discussion
CSF MOG-IgG is found in IDD other than MS and also in MS. In IDD other than MS, the CSF MOG-IgG positivity can support the diagnosis of MOGAD. The synthesis of MOG-IgG in the CNS of patients with MOGAD can be detected from the onset of the disease and is associated with the severity of the disease.
new medical entity set appart from MS: Anti-MOG
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