choose your favorite explanation

A forum to discuss research on the origins of MS and its development.
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Which theory do you think is right?

Poll ended at Thu Jun 28, 2018 12:28 am

neurodegeneration and inflammation driven by the same mechanism
0
No votes
primary neurodegeneration
1
100%
primary cytodegenerative processes/infections
0
No votes
 
Total votes: 1

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frodo
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choose your favorite explanation

Post by frodo » Tue May 29, 2018 12:28 am

This is about the secondary progressive phase enigmas.

Anti-inflammatory drugs that reduce inflammatory (immune) attacks in patients with RRMS fail to prevent disease progression in the SPMS phase. No animal models are available that mimic this behaviour and it does not fix into the autoimmune model. Three hypotheses have been proposed:

1) Inflammation in the relapsing-remitting and progressive phases is driven by the same mechanisms, but during progressive MS the central nervous system does not respond to currently available anti-inflammatory drugs (maybe because a closed blood-brain barrier)

2) Microglia, which are under the control of intact neurons, may become chronically active due to primary neurodegeneration, axonal degeneration, and some other processes.

3) Multiple sclerosis may be primarily caused by cytodegenerative processes/infections, which are amplified by inflammation

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461760/

Which one of these theories do you think is the right one? and, why?

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