Epstein Barr Virus review

[frodo]

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

http://www.nrronline.org/article.asp?is ... ulast=Guan

Conclusion

The conclusion drawn from the studies that are discussed in this review seems to align with a “fertile field hypothesis” which describes a heightened immunological state triggered by the initial viral infection.

This would ultimately decrease the threshold for activating auto-aggressive T-cells in the presence of later events. In order to accurately describe the role of viruses in MS, there is an urgent need to establish standardized virus screening protocols.

Nevertheless, recent B-cells research have become increasingly important for understanding the MS pathophysiology and may assist in addressing the potential link between EBV and MS tertiary lymphoid follicles comprising mainly of memory B-cells can be assessed by in vivo MRI imaging and might be useful in monitoring disease activity.