Epstein Barr Virus review

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frodo
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Epstein Barr Virus review

Post by frodo »

The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to in vivo imaging

http://www.nrronline.org/article.asp?is ... ulast=Guan

Conclusion

The conclusion drawn from the studies that are discussed in this review seems to align with a “fertile field hypothesis” which describes a heightened immunological state triggered by the initial viral infection.

This would ultimately decrease the threshold for activating auto-aggressive T-cells in the presence of later events. In order to accurately describe the role of viruses in MS, there is an urgent need to establish standardized virus screening protocols.

Nevertheless, recent B-cells research have become increasingly important for understanding the MS pathophysiology and may assist in addressing the potential link between EBV and MS tertiary lymphoid follicles comprising mainly of memory B-cells can be assessed by in vivo MRI imaging and might be useful in monitoring disease activity.
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Petr75
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Re: Epstein Barr Virus review

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2023 Feb 9
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Epstein-Barr virus as a leading cause of multiple sclerosis: mechanisms and implications
https://pubmed.ncbi.nlm.nih.gov/36759741/


Abstract

Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a rare complication of infection with the Epstein-Barr virus (EBV), a herpesvirus that infects more than 90% of the global population. This link was long suspected because the risk of MS increases markedly after infectious mononucleosis (symptomatic primary EBV infection) and with high titres of antibodies to specific EBV antigens. However, it was not until 2022 that a longitudinal study demonstrated that MS risk is minimal in individuals who are not infected with EBV and that it increases over 30-fold following EBV infection. Over the past few years, a number of studies have provided clues on the underlying mechanisms, which might help us to develop more targeted treatments for MS. In this Review, we discuss the evidence linking EBV to the development of MS and the mechanisms by which the virus is thought to cause the disease. Furthermore, we discuss implications for the treatment and prevention of MS, including the use of antivirals and vaccines.
https://www.eboro.cz
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