Report against division of MS in clinical types

[frodo]

It is interesting that this is finally getting contested, because it was introduced artificially by the pharma industry to get interferons approved.

Progressive Forms of Multiple Sclerosis: Distinct Entity or Age-Dependent Phenomena.

https://www.ncbi.nlm.nih.gov/pubmed/29157397

Abstract

In multiple sclerosis (MS), disease course is defined by a subclinical or clinical relapsing remitting phase, a progressive phase, and the overlapping phase in-between. Each phase can have intermittently active or inactive periods.

Subclinical activity in radiologically isolated syndrome evolving to primary-progressive MS is mostly indistinguishable from relapsing-remitting MS evolving to secondary-progressive MS.

The onset of progressive-phase MS is age-dependent but time and pre-progressive phase agnostic.

Pathologic hallmarks of progressive MS onset also appear to be age-dependent but pre-progressive phase agnostic. Onset of progressive MS is characterized by a peak in smoldering plaques.