More about Tcells. CD8+ Tcells dysregulation

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frodo
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More about Tcells. CD8+ Tcells dysregulation

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Alteration of CD8+ CD45RC in MS regulatory T cells functions

https://www.hal.inserm.fr/inserm-02159755/document

For the first time, we demonstrate an impairment of CD8+CD45RC(int) Tregs

We propose to define two populations of CD8+CD45RC Tregs:
  • CD8+CD45RC(int) are dysfunctional in severe MS patients and less frequent during exacerbations
  • CD8+CD45RC(neg) Tregs react properly to inflammation with enhanced regulatory functions during exacerbations
We suggest CD8+ CD45RC(int/neg) T cells and subsets may be potential therapeutic targets and prognostic tools in MS
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