https://www.hal.inserm.fr/inserm-02159755/document
For the first time, we demonstrate an impairment of CD8+CD45RC(int) Tregs
We propose to define two populations of CD8+CD45RC Tregs:
- CD8+CD45RC(int) are dysfunctional in severe MS patients and less frequent during exacerbations
- CD8+CD45RC(neg) Tregs react properly to inflammation with enhanced regulatory functions during exacerbations