MS defined as a CD8+ disease

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frodo
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MS defined as a CD8+ disease

Post by frodo » Thu Oct 17, 2019 3:01 am

This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing procedures.

The following paper defines and separates several diseases by their molecular causes, instead of using the clinical courses, and they separate two kinds of MS (with and without CD20+ b-cells):
  • CD4+ T‐cells/1–5: ADEM or Clippers, according to the clinical evolution.
  • CD4+ T‐cells, innate immune activation/6: A second kind of ADEM
  • CD4+ T‐cells and pathogenic autoantibodies/8–12 –7: Anti-MOG and NMO diseases
  • CD8+ T‐cells/13–21: Several diseases including non-standard multiple sclerosis
  • CD8+ T‐cells and CD20+ B‐cells/22–24: Standard multiple sclerosis
  • Innate immunity: Bacterial meningitis; chronic inflammatory conditions
More at:

https://onlinelibrary.wiley.com/doi/ful ... glia.23726

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frodo
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anti-CD20 therapy is also anti-CD8+

Post by frodo » Sun Nov 24, 2019 6:03 am

Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis

https://www.pnas.org/content/early/2019 ... 1915309116

Significance

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. CD8+ T cells have been strongly implicated in MS pathogenesis, but it is unclear whether myelin is a CD8+ T cell autoantigenic target in MS.

This study demonstrated that while myelin-specific CD8+ T cells are present at similar frequencies in untreated MS patients and healthy subjects, the proportion of memory and CD20-expressing myelin-specific CD8+ T cells was increased in MS patients, suggesting prior antigen encounter.

This activated phenotype was reversible as the memory and CD20-expressing populations of certain myelin-specific CD8+ T cells were reduced following anti-CD20 treatment.

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