MS defined as a CD8+ disease
Posted: Thu Oct 17, 2019 3:01 am
This is the first time that I see some kind of concrete definition for MS, instead of defining it by a collection of symptoms and testing procedures.
The following paper defines and separates several diseases by their molecular causes, instead of using the clinical courses, and they separate two kinds of MS (with and without CD20+ b-cells):
https://onlinelibrary.wiley.com/doi/ful ... glia.23726
The following paper defines and separates several diseases by their molecular causes, instead of using the clinical courses, and they separate two kinds of MS (with and without CD20+ b-cells):
- CD4+ T‐cells/1–5: ADEM or Clippers, according to the clinical evolution.
- CD4+ T‐cells, innate immune activation/6: A second kind of ADEM
- CD4+ T‐cells and pathogenic autoantibodies/8–12 –7: Anti-MOG and NMO diseases
- CD8+ T‐cells/13–21: Several diseases including non-standard multiple sclerosis
- CD8+ T‐cells and CD20+ B‐cells/22–24: Standard multiple sclerosis
- Innate immunity: Bacterial meningitis; chronic inflammatory conditions
https://onlinelibrary.wiley.com/doi/ful ... glia.23726