There is also demyelination outside the lesions
Posted: Thu Oct 24, 2019 8:03 am
[18F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis
https://link.springer.com/article/10.10 ... 19-04533-y
Conclusion
Our findings demonstrate that [18F]florbetapir PET imaging can measure in-vivo myelin damage in patients with MS. Demyelination in MS is not restricted to lesions detected through conventional MRI but also involves the normal appearing white matter. Although longitudinal studies are needed, [18F]florbetapir PET imaging may have a role in clinical settings in the management of MS patients.
https://link.springer.com/article/10.10 ... 19-04533-y
Conclusion
Our findings demonstrate that [18F]florbetapir PET imaging can measure in-vivo myelin damage in patients with MS. Demyelination in MS is not restricted to lesions detected through conventional MRI but also involves the normal appearing white matter. Although longitudinal studies are needed, [18F]florbetapir PET imaging may have a role in clinical settings in the management of MS patients.