There is also demyelination outside the lesions

[frodo]

[18F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosis

https://link.springer.com/article/10.10 ... 19-04533-y

Conclusion

Our findings demonstrate that [18F]florbetapir PET imaging can measure in-vivo myelin damage in patients with MS. Demyelination in MS is not restricted to lesions detected through conventional MRI but also involves the normal appearing white matter. Although longitudinal studies are needed, [18F]florbetapir PET imaging may have a role in clinical settings in the management of MS patients.