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is MS an autoimmune disease?

Posted: Wed Dec 18, 2019 7:19 am
by frodo
This paper lists evidence for and against the autoimmune classification. It is interesting to note that one of the main reasons supporting autoimmunity is the presence of anti-MOG auto-antibody (which is not considered MS anymore)

The whole article is available at:


Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) with varied clinical presentations and heterogeneous histopathological features. The underlying immunological abnormalities in MS lead to various neurological and autoimmune manifestations. There is strong evidence that MS is, at least in part, an immune-mediated disease. There is less evidence that MS is a classical autoimmune disease, even though many authors state this in the description of the disease. We show the evidence that both supports and refutes the autoimmune hypothesis. In addition, we present an alternate hypothesis based on virus infection to explain the pathogenesis of MS.