NAWM (normal appearing white matter) description

[frodo]

Two new papers about NAWM that point to metabolic changes

perilesional-NAWM is characterized by lower myelin and axonal content compared to contralateral-NAWM, suggestive of degenerative changes extending outside lesions. We are further working on assessing the impact of lesional disease on distant degeneration and its effect on clinical outcome.

https://n.neurology.org/content/94/15_S ... 4.abstract

Although the BBB permeability for GBCA in non-enhancing MS lesions is several orders of magnitude lower than that of enhancing MS lesions, our study observed significantly lower water exchange. The lower BBB water exchange observed in RRMS lesions is consistent with previously reported observations and may demonstrate metabolic changes associated with MS.

https://www.sciencedirect.com/science/a ... 5X20300758