Unknown circulating serum factors impair BBB integrity
Posted: Thu May 14, 2020 5:25 am
Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier
https://jneuroinflammation.biomedcentra ... 20-01810-8
Conclusions
Our data suggest that circulating factors present in RRMS patient serum induce physiological and biochemical alterations to the BBB, namely reducing expression of essential tightness regulators, as well as reduced engagement of glycolysis and alteration of mitochondrial potential.
As these last changes have been linked with alterations in nutrient usage and metabolic function in immune cells; we propose that the BBB endothelium of MS patients may similarly undergo metabolic dysregulation, leading to enhanced permeability and increased disease susceptibility.
https://jneuroinflammation.biomedcentra ... 20-01810-8
Conclusions
Our data suggest that circulating factors present in RRMS patient serum induce physiological and biochemical alterations to the BBB, namely reducing expression of essential tightness regulators, as well as reduced engagement of glycolysis and alteration of mitochondrial potential.
As these last changes have been linked with alterations in nutrient usage and metabolic function in immune cells; we propose that the BBB endothelium of MS patients may similarly undergo metabolic dysregulation, leading to enhanced permeability and increased disease susceptibility.