Nanoimmunosensor based on atomic force spectroscopy to detect anti-myelin basic protein related to early-stage multiple sclerosis
https://www.sciencedirect.com/science/a ... 9119301019
Highlights
• Atomic force spectroscopy nanoimmunosensor detected anti-MBP in multiple sclerosis.
• Anti-MBP was present in early-stage and absent in advanced-stage MS patients.
• Nanoimmunosensor test had 96.68% of sensitivity and 68.48% of specificity.
• The optimal point of accuracy resulted in a cut-off value of 201.4 pN.
• Adhesion force values from simulations and experiments were similar.
Biomarker: Antibodies in the patients’ cerebrospinal fluid are attracted to some peptides
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