PET differentiates pathological variants of MS

[frodo]

TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis

Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló’s Concentric Sclerosis

https://journals.lww.com/nuclearmed/Abs ... 96521.aspx

Abstract

PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia.

Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using 18F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló’s concentric sclerosis.

Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.