Twins comparison suggest lipids metabolism implications

A forum to discuss research on the origins of MS and its development.
Post Reply
User avatar
Family Elder
Posts: 1554
Joined: Wed Dec 02, 2009 3:00 pm

Twins comparison suggest lipids metabolism implications

Post by frodo » Thu Nov 12, 2020 4:04 am

Plasma lipidomics of monozygotic twins discordant for multiple sclerosis ... acn3.51216


Blood biomarkers of multiple sclerosis (MS) can provide a better understanding of pathophysiology and enable disease monitoring. Here, we performed quantitative shotgun lipidomics on the plasma of a unique cohort of 73 monozygotic twins discordant for MS.

We analyzed 243 lipid species, evaluated lipid features such as fatty acyl chain length and number of acyl chain double bonds, and detected phospholipids that were significantly altered in the plasma of co‐twins with MS compared to their non‐affected siblings.

Strikingly, changes were most prominent in ether phosphatidylethanolamines and ether phosphatidylcholines, suggesting a role for altered lipid signaling in the disease.

Post Reply
  • Similar Topics
    Last post

Return to “MS Etiology and Pathogenesis”