B Cell Dysfunction, Aging, Autoimmune Diseases

A forum to discuss research on the origins of MS and its development.
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jimmylegs
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B Cell Dysfunction, Aging, Autoimmune Diseases

Post by jimmylegs »

starting to work on getting my head around anti b cell meds...

B Cell Dysfunction Associated With Aging and Autoimmune Diseases (2019)
fft: https://www.frontiersin.org/articles/10 ... 00318/full

"... The discovery of a subset of B cells, termed age-associated B cells (ABCs), has drawn significant attention in recent years. Initially isolated from aged donors and found to be closely associated with immune senescence, these cells were expected to provide a novel therapeutic avenue for autoimmune diseases. With due consideration to various aspects of their potential, we review previous findings and provide an insight into the properties, functions, and related signaling pathways, which may assist in developing a better understanding of this subset of B cells (Table 1)."
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jimmylegs
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by jimmylegs »

treadmill mice :lol:

" ... Although total peripheral B cell counts remain relatively stable in adulthood (8), aging has been associated with a decline in B cell production in the bone marrow."

and so the possibilities for slowing aging in bone marrow might be ... ??

Physical Activity Increases the Total Number of Bone-Marrow-Derived Mesenchymal Stem Cells, Enhances Their Osteogenic Potential, and Inhibits Their Adipogenic Properties (2015)
https://www.hindawi.com/journals/sci/2015/379093/

" Aging and sedentary lifestyle are common nowadays and are associated with the increasing number of chronic diseases. Thus, physical activity is recommended as one of three healthy behavior factors that play a crucial role in health prophylaxis. ... EX may represent a novel, nonpharmacological strategy of slowing down age-related decline of the musculoskeletal functions."
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by jimmylegs »

moar mice, but

DHA‐enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function (2013)
fft: https://jlb.onlinelibrary.wiley.com/doi ... lb.0812394

"... This study tested the hypothesis that DHA from fish oil is incorporated into the B cell membrane to alter lipid microdomain clustering and enhance B cell function ... These results support the hypothesis and an emerging concept that fish oil enhances B cell function in vivo."
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

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Chronic intake of high fish oil diet induces myeloid-derived suppressor cells to promote tumor growth (2014)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246012/

had to unpack that one. "Fish oil diet contains 40 mg EPA and 26 mg DHA per gram diet (vs. 0 in High Fat Western Diet) (Table 1)."
  • so for a 1600 calorie diet, using all eggs, that would be about 10 eggs for 560 grams of food.
  • so 560 grams x 66 mg/gram = 36960 mg. or 36.9 gm fish oil per day
contrast beneficial fish oil research at 3 gm fish oil per day (10 capsules)

so unless my math is right out to lunch, the takeaway looks like: be careful not to accidentally take over 120 capsules of fish oil on a daily basis over the long term (or if you have capsules like the ones i use, over 60...).
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by NHE »

jimmylegs wrote: Sat May 15, 2021 1:09 pmso unless my math is right out to lunch, the takeaway looks like: be careful not to accidentally take over 120 capsules of fish oil on a daily basis over the long term (or if you have capsules like the ones i use, over 60...).
Too much of a good thing can be problematic.

Too much water can dilute your electrolytes and kill you.
viewtopic.php?p=23383#p23383

Too much green tea can inhibit folate leading to a B12 deficiency causing irreversible disability from spinal cord demyelination known as subacute combined degeneration.
viewtopic.php?p=237383#p237383
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by DIM »

NHE wrote: Sun May 16, 2021 3:08 am Too much green tea can inhibit folate leading to a B12 deficiency causing irreversible disability from spinal cord demyelination known as subacute combined degeneration.
viewtopic.php?p=237383#p237383
Moreover it's high caffeine content will lower uric acid level that is beneficial as peroxynitrite scavenger
jimmylegs
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by jimmylegs »

guess who? mice...

Post-stroke administration of omega-3 polyunsaturated fatty acids promotes neurovascular restoration after ischemic stroke in mice: Efficacy declines with aging (2019)
https://www.sciencedirect.com/science/a ... 6118305734

"... neurological benefits of n-3 PUFA administration after stroke extend to older animals and are associated with improved neuronal survival and brain remodeling, ..."
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Re: B Cell Dysfunction, Aging, Autoimmune Diseases

Post by jimmylegs »

haven't gotten through this one yet, or even figured out if i can get full text. interesting looking objectives, though.

Thymosin-α1 expands deficient IL-10-producing regulatory B cell subsets in relapsing–remitting multiple sclerosis patients (2017)
https://journals.sagepub.com/doi/abs/10 ... 8517695892

Objectives:
Moving from our data showing a Toll-like receptor (TLR)7-driven dysregulation of B cell response in relapsing–remitting multiple sclerosis (RRMS) and having found a low serum level of Thymosin-α1 (Tα1) in patients, we investigated whether the addition of this molecule to peripheral blood mononuclear cells (PBMCs) would influence the expansion of regulatory B cell subsets, known to dampen autoimmune inflammation.
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