The authors propose that some existing drugs could be repurposed to target each the genetic pathway.
An integrative study of genetic variants with brain tissue expression identifies viral etiology and potential drug targets of multiple sclerosis
https://www.sciencedirect.com/science/a ... pKP-Wqh5A0
Highlights
• Cross Dataset Evaluation was developed to investigate NAWM and the largest MS GWAS.
• Rubidomycin and zafirlukast are drugs suggested to be repurposed for MS treatment.
• MAPK and JAK2/STAT3 pathways are identified as major potential drug targets in MS.
• Prioritized genes for MS risk: CDK4, IFITM3, MAPK1, MAPK3, METTL12B and PIK3R2
• Conjectural mechanisms of viral involvement in MS etiology are presented.
Genome Wide Associated Study: Genes involved in lesion locations
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 958 Views
-
Last post by NHE
-
- 0 Replies
- 1788 Views
-
Last post by frodo
-
- 0 Replies
- 1272 Views
-
Last post by frodo
-
- 0 Replies
- 1038 Views
-
Last post by frodo
-
- 0 Replies
- 1012 Views
-
Last post by frodo
-
- 0 Replies
- 1768 Views
-
Last post by frodo
-
- 0 Replies
- 1936 Views
-
Last post by DIM
-
- 0 Replies
- 1728 Views
-
Last post by DIM
-
- 0 Replies
- 1853 Views
-
Last post by Tif