Surface-in pathology in multiple sclerosis: a new view on pathogenesis?
https://academic.oup.com/brain/article- ... 46/6238675
Abstract
While multiple sclerosis can affect any part of the CNS, it does not do so evenly.
In white matter it has long been recognized that lesions tend to occur around the ventricles, and grey matter lesions mainly accrue in the outermost (subpial) cortex.
In cortical grey matter, neuronal loss is greater in the outermost layers. This cortical gradient has been replicated in vivo with magnetization transfer ratio and similar gradients in grey and white matter magnetization transfer ratio are seen around the ventricles, with the most severe abnormalities abutting the ventricular surface.
The cause of these gradients remains uncertain, though soluble factors released from meningeal inflammation into the CSF has the most supporting evidence.
In this Update, we review this ‘surface-in’ spatial distribution of multiple sclerosis abnormalities and consider the implications for understanding pathogenic mechanisms and treatments designed to slow or stop them.
soluble factors released from meningeal inflammation as the culprit
-
- Similar Topics
- Replies
- Views
- Last post
-
- 1 Replies
- 1391 Views
-
Last post by frodo
-
- 0 Replies
- 2118 Views
-
Last post by frodo
-
- 1 Replies
- 1001 Views
-
Last post by Leonard
-
- 0 Replies
- 2517 Views
-
Last post by frodo
-
- 0 Replies
- 1320 Views
-
Last post by NHE
-
- 0 Replies
- 1443 Views
-
Last post by frodo
-
- 2 Replies
- 3254 Views
-
Last post by frodo
-
- 6 Replies
- 1809 Views
-
Last post by DIM
-
- 0 Replies
- 1689 Views
-
Last post by NHE