diagnosis by proteins in tears

[frodo]

Experimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis

https://www.mdpi.com/1424-8220/23/11/5251

Conclusions

According to this study, MS patients have altered tear proteomes. The tear proteome may be a good indicator of MS-related disorders and CNS inflammation.

Tear fluid is not a biological substance that is frequently employed in clinico-biochemical laboratories. The vast diagnostic potential of such a small volume is currently only being explored experimentally. In this research, specific experimental and computer-solved techniques for MS patients’ tear fluid are described.

In conclusion, it is known that a variety of conditions can raise the probability that MS will develop and progress, but the exact cause of this illness is still mostly unknown. The development of MS is closely associated with stress and disruption of lipid metabolism, as is common for other inflammatory neurodegenerative disorders.

An autoimmune inflammatory response directed largely against the oligodendrocytes in the CNS triggers the onset of MS and results in demyelination and inflammation. After a period, when the oligodendrocytes’ potential for regeneration is depleted, the inflammatory processes affect the neurons themselves, causing neurodegeneration and lasting damage to the CNS.

By offering a thorough investigation of the proteome profile of MS patients, experimental proteomics has the potential to be used in clinical practice for the diagnosis of MS.

Finally, clinical proteomic analysis techniques may develop into a modern tool for personalized therapy.

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