The endocannabinoid 2-AG

Medical Marijuana in the treatment of Multiple Sclerosis.
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Petr75
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The endocannabinoid 2-AG

Post by Petr75 » Wed Jan 16, 2019 12:21 pm

2018 Dec 21
Departamento de Neurobiología Funcionaly de Sistemas, Grupo de Neuroinmunología, Instituto Cajal, CSIC, Spain
The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
https://www.ncbi.nlm.nih.gov/pubmed/30582962

Abstract
Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, although it is often incomplete or fails to affect the integrity of the axon, thereby leading to progressive disability. Microglia play a crucial role in the clearance of the myelin debris produced by demyelination and in inflammation-dependent OPC activation, two processes necessary for remyelination to occur. We show here that following corpus callosum demyelination in the TMEV-IDD viral murine model of MS, there is spontaneous and partial remyelination that involves a temporal discordance between OPC mobilization and microglia activation. Pharmacological treatment with the endocannabinoid 2-AG enhances the clearance of myelin debris by microglia and OPC differentiation, resulting in complete remyelination and a thickening of the myelin sheath. These results highlight the importance of targeting microglia during the repair processes in order to enhance remyelination.

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NHE
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Re: The endocannabinoid 2-AG

Post by NHE » Wed Jan 16, 2019 7:03 pm

Petr75 wrote:2018 Dec 21
Departamento de Neurobiología Funcionaly de Sistemas, Grupo de Neuroinmunología, Instituto Cajal, CSIC, Spain
The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia
https://www.ncbi.nlm.nih.gov/pubmed/30582962

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https://linkinghub.elsevier.com/retriev ... 18)30241-1

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