Effects of THC/CBD oromucosal spray
Effects of THC/CBD oromucosal spray
Department "G.F. Ingrassia", section of Neurosciences, University of Catania, Catania, Italy
Effects of THC/CBD oromucosal spray on spasticity-related symptoms in people with multiple sclerosis: results from a retrospective multicenter study.
https://www.ncbi.nlm.nih.gov/pubmed/32335779
Abstract
INTRODUCTION:
The approval of 9-δ-tetrahydocannabinol (THC)+cannabidiol (CBD) oromucosal spray (Sativex®) in Italy as an add-on medication for the management of moderate to severe spasticity in multiple sclerosis (MS) has provided a new opportunity for MS patients with drug-resistant spasticity. We aimed to investigate the improvement of MS spasticity-related symptoms in a large cohort of patients with moderate to severe spasticity in daily clinical practice.
MATERIALS AND METHODS:
MS patients with drug-resistant spasticity were recruited from 30 Italian MS centers. All patients were eligible for THC:CBD treatment according to the approved label: ≥ 18 years of age, at least moderate spasticity (MS spasticity numerical rating scale [NRS] score ≥ 4) and not responding to the common antispastic drugs. Patients were evaluated at baseline (T0) and after 4 weeks of treatment (T1) with the spasticity NRS scale and were also asked about meaningful improvements in 6 key spasticity-related symptoms.
RESULTS:
Out of 1615 enrolled patients, 1432 reached the end of the first month trial period (T1). Of these, 1010 patients (70.5%) reached a ≥ 20% NRS score reduction compared with baseline (initial responders; IR). We found that 627 (43.8% of 1432) patients showed an improvement in at least one spasticity-related symptom (SRSr group), 543 (86.6%) of them belonging to the IR group and 84 (13.4%) to the spasticity NRS non-responders group.
CONCLUSION:
Our study confirmed that the therapeutic benefit of cannabinoids may extend beyond spasticity, improving spasticity-related symptoms even in non-NRS responder patients.
-
- Similar Topics
- Replies
- Views
- Last post
-
- 0 Replies
- 973 Views
-
Last post by Petr75
Mon Feb 24, 2020 9:25 am
-
- 1 Replies
- 63 Views
-
Last post by NHE
Sat Jan 23, 2021 3:26 am
-
-
The protective effects of β-caryophyllene
by Petr75 » Tue Jan 29, 2019 4:56 am » in Medical Marijuana - 0 Replies
- 1702 Views
-
Last post by Petr75
Tue Jan 29, 2019 4:56 am
-
-
- 1 Replies
- 170 Views
-
Last post by NHE
Thu Jul 09, 2020 4:58 pm
-
-
Vumerity may have less GI side effects.
by NHE » Tue Jun 30, 2020 8:07 am » in Vumerity (diroximel fumarate) - 0 Replies
- 178 Views
-
Last post by NHE
Tue Jun 30, 2020 8:07 am
-
-
-
The effects of a combination of ion channel inhibitors
by Petr75 » Thu Aug 08, 2019 7:21 am » in General Discussion - 0 Replies
- 884 Views
-
Last post by Petr75
Thu Aug 08, 2019 7:21 am
-
-
- 1 Replies
- 2264 Views
-
Last post by Petr75
Thu Oct 03, 2019 10:54 am
-
-
Effects of Exercise on Brain Structure and Cognitive Function
by NHE » Sat Nov 14, 2020 4:17 am » in Exercise and Physical Therapy - 0 Replies
- 163 Views
-
Last post by NHE
Sat Nov 14, 2020 4:17 am
-