Posted: Thu Jun 09, 2011 12:01 pm
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Wow. What a wild discussion.bromley wrote:For those who are interested in DMDs and may have to make a decision on which one to take... the following may be of interest (a bit techy, but a lot of information):
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100222/
I also plan to use my own version of rainer’s suggestion to figure this out for myself:Please remember that all agents are associated with particular side-effects and other attributes; hence the decision on which one is more appropriate for a particular person will require some careful thought. Individualised Medicine!
NHE, thanks for the info on dimethyl fumarate (I guess I initiated that wild detour by adding the names to the meds.)Would love to see percentages of the non-orals too. Have always thought we need a sabermeteric analysis of treatments. For you non North Americans - http://en.wikipedia.org/wiki/Sabermetrics
Good luck with your decision! And everyone, keep smiling.I hope the original poster got the the help he/she wanted!
Yes, Lyon, you're right. That's the exact link that Bromley posted, that I reposted in the post I just made (right above yours), and then I went on and on about it (see below). And now I'm reposting it again (see below). I liked it. And I don't recall ever seeing a thread that wandered the way this one has, with so little attention to what was previously posted...Lyon wrote:euphoniaa,
I think this one might have been posted elsewhere but seems pertinent here, although in the past 9 or 10 days Becia might have already decidedhttp://www.ncbi.nlm.nih.gov/pmc/article ... ool=pubmedBecia wrote:thinking swap from copaxone to C but need more information.please help
bromley wrote:
For those who are interested in DMDs and may have to make a decision on which one to take... the following may be of interest (a bit techy, but a lot of information):
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100222/
But...the review document that Bromley linked in his post (see above) is excellent reading (Development of oral immunomodulatory agents in the management of multiple sclerosis) and included Cladribine. Some info was “techie” but it really went into detailed comparisons of the pros/cons of both the new orals and the older injectable/infusable ones. It then extended into an informative section on “Patient-focused perspectives” with an overview of DMDs in general.
Nah, not a hard man at all...once you get to know me And BTW, it was Ian who first e-mailed me to explain his posts.You're a hard man HarryZ. You admit that you've evidently spend a bit of time corresponding with Ian, likely trying to gain his confidence. I had you pegged as the kind of guy who found the good in everyone.
You tell me.....out of the entire history of thisisms who else other than Ian are you aware of sending fine chocolates to friend and foe alike? Can you proclaim better evidence of a kind heart?
It's best not to make assumptions. I took no offense at anything you posted. My reply was due to confusion as you had chosen not to quote the original text you were commenting on making it difficult to determine which post you were referencing.jgkarob wrote:I was brave and corrected this view, only to have NHE taking offence at what I posted.
I doubt that anyone here at ThisIsMS honestly takes pleasure in the misfortunes of others. We are all here since we have to fight a common enemy, MS, and hopefully not each other.Fine - but no one thought about how all this glee and schadenfreuden affected those people who were fine taking their DMDs and if you have non-progressive RRMS, relapse reduction is paramount.
I'm honestly happy to hear that you're doing better. With so many variables to consider, it would be difficult to narrow down your improvements to any one specific element. Sometimes though, we have to throw everything we can at this disease in order to make any progress.I'm not a drug rep, just a person who feels extremely fortunate that Rebif actually worked and without fluey side-effects. I'm an idiot for posting this, but it's time that someone wrote how this board affects them.
Incidentally, I'm not well because of Rebif. I'm well now, through a strict diet, LDN, Vitamin D3 and B12 and a lot of exercise and also because I had to move to a country with less humidity. I left my family behind to keep my mobility. We live in extraordinary poverty, but at least I can walk down the street here, without losing my balance and focus, which would happen in less than 5 minutes in the UK.
There, I was housebound. Here, I'm not.
I'm not sure that I would agree with you on that statement. I (don't have MS but my wife did for 35 years) and many others have lived through the development, release and subsequent general use of the DMDs. While highly touted when they first came out, their (CRABs)overall effectiveness has greatly diminished. Even the experienced MS docs will tell you that. But that doesn't mean that they don't work for some people. They do but for a small minority.Fine - but no one thought about how all this glee and schadenfreuden affected those people who were fine taking their DMDs and if you have non-progressive RRMS, relapse reduction is paramount.
Awww I care! Even though his original post nearly caused my early demise when I choked on my cup of tea....The second reason for my post: None of bromley's friends cared about bromley.