Safety and efficacy of ozanimod vs. fingolimod
Posted: Sat Apr 25, 2020 2:33 am
Comparative safety and efficacy of ozanimod versus fingolimod for relapsing multiple sclerosis.
J Comp Eff Res. 2020 Mar;9(4):275-285.
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J Comp Eff Res. 2020 Mar;9(4):275-285.
- Aim: Ozanimod and fingolimod are sphingosine 1-phosphate receptor-modulating therapies for relapsing multiple sclerosis.
Patients & methods: Comparative effectiveness was assessed by matching adjusted indirect comparisons of safety and efficacy trial outcomes at first-dose cardiac monitoring, 1 year and 2 years.
Results: After adjustment, baseline characteristics were similar. Ozanimod was associated with a lower risk of extended first-dose monitoring, conduction abnormalities including atrioventricular block. One-year risks of any adverse event (AE), mean lymphocyte count reductions and abnormal liver enzymes were lower with ozanimod. Two-year risks of AEs leading to discontinuation, any AEs, herpetic infections, bradycardia and abnormal liver enzymes were lower with ozanimod. Analyses of efficacy outcomes were similar.
Conclusion: Ozanimod appears to have a favorable benefit-risk profile versus fingolimod.
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