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Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Posted: Sat Dec 22, 2018 11:27 am
by jimmylegs
update - found some research in support of several smaller doses through the day with no food. the small doses would probably dodge the nausea bullet so the food wouldn't be needed anyway. the study i was looking at used 3x50mg but i personally would be more inclined to sprinkle a few 25mg doses through the day with 100mg as the max (also keeping in mind over the long term that 40mg is considered the safe upper limit for daily ainc supplementation).

Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Posted: Wed Jan 02, 2019 10:12 am
by Jaded
Ok thanks. I've been taking 50mg daily!

Re: 2000 review: Dietary Factors Influencing Zinc Absorption

Posted: Thu Jan 03, 2019 7:26 am
by jimmylegs
i did for a long time as well, but i was hopefully rebuilding tissue stores after a decade plus of negligible zinc in diet :)
for that matter, i'm on 50mg + per day at the moment (up to 50 via single capsule, up to 10 via multi), 5 days per week.
works out to max 43mg/d overall, not too bad.

2019 meta analysis: Vegan/vegetarianism, BMD & fracture risk

Posted: Thu Jan 03, 2019 7:30 am
by jimmylegs
hope the recent decade plus of hard work on nutrition has helped to mitigate my prior decade plus of uninformed vegan idealism :)

Veganism, vegetarianism, bone mineral density, and fracture risk: a systematic review and meta-analysis (2019) ... /1/5146363
  • Results
    Twenty studies including 37 134 participants met the inclusion criteria. Compared with omnivores, vegetarians and vegans had lower BMD at the femoral neck and lumbar spine and vegans also had higher fracture rates.

    Vegetarian and vegan diets should be planned to avoid negative consequences on bone health.

2016 trial: anti-inflammatory regimen in RRMS & PPMS

Posted: Thu Jan 10, 2019 2:42 pm
by jimmylegs
Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study (2016)

"In our study, it was shown that:

All MS patients had insufficient or sub-optimal levels of vitamin D3. It can be suggested that this is a common condition in MS patients;
Vitamin D3 nutritional status of patients was not ameliorated, neither by administration of vitamin D3 at ca. 1.5 fold the RDA dose nor by combined administration of IFN-β, with or without dietary management or dietary supplements;

A dietary regimen, mainly based on principles of Mediterranean diet, with or without administration of dietary supplements, determined an increase of the rate n-3/n-6 PUFA serum concentration thus supporting the general trend towards an amelioration of inflammatory status. This was established in 12 out of 29 patients, on the basis of reduced active MMP-9 levels in the RRTD, RRTDI and PPMS groups), and of anthropometric parameters as well. PPMS patients were more responsive to the nutritional intervention with fish oil and lipoic acid."

let's take a closer look at that regimen...

"Dietary supplements, daily dosage, and duration of administration

Dibase Abiogen Pharma, vitamin D3 (cholecalciferol), 714 IU/day (5000 IU, once the week, for five months) + 200 IU with a multivitamin complex (Vit M O.T.I.) (daily administration for four months).
Vit M O.T.I., multivitamin complex (including oligoelements), per day, for four months: vitamins: C (120 mg), PP (36 mg), E (20 mg), B6 (4 mg), B2 (3.2 mg), B1 (2.8 mg), B12 (2 mcg), A (1.6 mg), D3 (5 mcg); biotin (0.3 mg), pantothenic acid (12 mg), folic acid (0.4 mg); oligoelements: zinc (30 mg), iron (28 mg), copper (3 mg), manganese (3 mg), selenium (120 mcg), fluorine (3 mg), iodine (0.3 mg)."

so low daily d3 and no magnesium at all, interesting design choices :S ...

Palaeodiet reconstruction, Southern Ontario (1985)

Posted: Fri Jan 11, 2019 11:47 am
by jimmylegs
working on something else entirely, from the top results for a basic search on southern ontario

Stable isotopes in human skeletons of Southern Ontario: reconstructing Palaeodiet (1985) ... 0385900202

Most native plants of Ontario use the C3 photosynthetic mechanism and therefore have relatively low ratios; maize is a C4 plant and is relatively enriched in 13C. The proportion of maize in the diet of a human can therefore be estimated from the 13C-content of collagen of fossil bone. We have used this method to follow the increase in consumption of maize in ancient native populations over the interval from AD 400 to 1650, and to quantify the amount of maize consumed. Maize consumption rose gradually to a maximum of 50% of the diet by AD 1400. These data agree with archaeologically derived data for this region, and with previous isotope studies in the northeastern U.S.A. In some of the latter, however, the maximum percentage of maize consumed has been overestimated because maize was assumed to have a δ13C value of −12·5‰; our studies of archaeological specimens show the correct value to be closer to −9‰. The introduction of beans into the native diet about AD 1100, should have caused a decrease in the 15N content of human bone collagen because legumes are deficient in this isotope, with respect to meat and fish. However, we observe no significant change in the N ratio of human bone collagen over the period from 2300 BC to AD 1640. We conclude that meat and fish remained the main sources of protein even after the advent of agriculture into this region.

2019 review: Diet and MS - Web-Based Recommendations

Posted: Wed Feb 06, 2019 8:01 am
by jimmylegs
  • Diet and Multiple Sclerosis: Scoping Review of Web-Based Recommendations (2019)

    There is currently no scientific evidence supporting the use of specific diets in the management of multiple sclerosis (MS); the strongest dietary associations are observed with vitamin D and omega-3 fatty acid supplementation. Despite this, there are many websites that provide advice or suggestions about using various dietary approaches to control symptoms or disease progression.
    In conclusion, there is a wide variety of Web-based dietary advice that, in some cases, offers contradictory advice. In many cases, this advice is the result of peoples’ individual experiences and has not been scientifically tested. The public is advised to assess the reliability of health information provided on the internet by looking for details such as authorship, and supporting evidence, such as the citation of scientific literature. However, we found webpages that would normally be considered reliable (eg, MS Society) did not perform well in this regard. Conversely, some webpages appeared credible due to the provision of links to scientific literature, but the cited material did not always support the advice given. Patients without scientific training, and likely to lack the knowledge required to interpret the conflicting and often unsupported advice given, are left to assess whether the information being provided is reliable. These findings highlight the role health professionals can have in providing the best quality information to consumers on relevant topics in a way that is easy to understand, accurate, and accessible. Future work should focus on determining what decisions people make from accessing Web-based information and the proportion of people who actually follow the different dietary regimes promoted on the Web, what factors led them to choose that particular approach, and what, if any, effects (positive or negative) have resulted from making these dietary

2017: red meat caveat

Posted: Fri Feb 15, 2019 6:23 pm
by jimmylegs
this article's subject matter is something that does concern me for a number of reasons...

Associations between Red Meat Intakes and the Micronutrient Intake and Status of UK Females: A Secondary Analysis of the UK National Diet and Nutrition Survey (2017)

"Blanket health messages to lower red meat intakes are being communicated at present. These could have adverse implications on the micronutrient quality of women’s diets. ... Females consuming less than 40 g total red meat daily were more likely to have micronutrient intakes below the Lower Reference Nutrient Intake (LRNI) for zinc, iron, vitamin B12 and potassium and have lower habitual vitamin D intakes than females consuming between 40 and 69 g daily. ... Females consuming diets lower in red meat, i.e., <40 g daily, appear to have reduced micronutrient intakes, especially in the case of zinc and vitamin D. This should be considered when giving blanket advice for whole populations to reduce red meat intakes."

now to go track down the men's version. and for the time being, to consider what this means in terms of servings per week:

lower end of range for red meat - 40g x 7d = 280g/wk
per new canada food guide 75g (2.5 oz) serving = 3.7 servings/wk
per mediterranean diet 60g (2 oz) serving = 4.66 servings/wk

upper boundary 69x7 = 483g
483/75 = 6.44 svg/wk
483/60 = 8 svg/wk

so for one year using the lower end of the intake range:
14.6 kg or 32 lbs

in the U.S. ... meat is consumed at more than three times the global average
According to NHANES 2003–2004, total meat intake averaged 128 g/day ...
red meat still represents the largest proportion of meat consumed in the U.S (58%).

so 27 kg or 60 lbs.

diet, late onset MS?

Posted: Mon Sep 07, 2020 7:02 am
by jimmylegs

Diet quality is not associated with late-onset multiple sclerosis risk– A Danish Cohort Study (2020) ... 4820300444

i may take a closer look at the
"tertiles of diet quality, assessed by means of the Alternative Healthy Eating Index-2010."

i would also be interested to know whether there was in fact a positive association, albeit one that did not achieve statistical significance.

Re: Diet & MS Research

Posted: Tue Sep 08, 2020 12:24 am
by Petr75
Interesting link.

Diet at MS will not be the main driving force.
Vikings, they ate well. And some of them still had MS.

early ms: prudent diet & relapse risk

Posted: Tue Sep 08, 2020 9:44 am
by jimmylegs
:) i still haven't looked at the viking details above, or the prudent dtls for the below

High Prudent diet factor score predicts lower relapse hazard in early multiple sclerosis (2020)

"...Prudent diet factor score above the median was prospectively associated with lower relapse risk in the 5 years following the first clinical demyelinating event."

Re: Diet & MS Research

Posted: Tue Sep 08, 2020 10:46 am
by Petr75
The point was - even though the Vikings had a good diet (in my opinion - a good one), some of them still got MS.
Viking was an idea, so no connection. :wink:

Re: Diet & MS Research

Posted: Tue Sep 08, 2020 1:26 pm
by jimmylegs
and i still haven't looked at the details, irrespective of the authors' terms for the study subjects :)

neuros, diet & you

Posted: Tue Sep 08, 2020 2:32 pm
by jimmylegs
The unresolved role of the neurologist in providing dietary advice to people with multiple sclerosis (2020) ... 4820303801

"... Neurologists could meet their patients’ expectations by providing evidence-based dietary advice, such as promoting the benefits of diets that adhere to national dietary guidelines, and being prepared to explain potential risks of restrictive diets. Information about healthy eating needs to be targeted to people with MS."

MS/EAE Dietary Factors

Posted: Wed Sep 30, 2020 7:57 am
by jimmylegs
Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review (2020)

"... Results: While there is currently little data for any specific diet in MS, there is growing evidence that certain dietary factors may influence the disease.
Conclusions: Definitive information regarding dietary factors as a modifiable risk factor in MS will require larger randomized clinical trials."

keeping in mind:

Perspective: Fundamental Limitations of the Randomized Controlled Trial Method in Nutritional Research: The Example of Probiotics (2018)
"...In this perspective, we investigate whether there are fundamental limitations of the RCT method in nutritional research. .."

13. Heaney RP. Nutrients, endpoints, and the problem of proof. J Nutr [Internet] 2008;138:1591–5.

14. Satija A, Yu E, Willett WC, Hu FB. Understanding nutritional epidemiology and its role in policy. Adv Nutr [Internet] 2015;6:5–18.

15. Hébert JR, Frongillo EA, Adams SA, Turner-McGrievy GM, Hurley TG, Miller DR, Ockene IS. Perspective: randomized controlled trials are not a panacea for diet-related research. Adv Nutr [Internet] 2016;7:423–32. ... 23/4558105

(short story, consider study design carefully)