Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study (2016)
"In our study, it was shown that:
All MS patients had insufficient or sub-optimal levels of vitamin D3. It can be suggested that this is a common condition in MS patients;
Vitamin D3 nutritional status of patients was not ameliorated, neither by administration of vitamin D3 at ca. 1.5 fold the RDA dose nor by combined administration of IFN-β, with or without dietary management or dietary supplements;
A dietary regimen, mainly based on principles of Mediterranean diet, with or without administration of dietary supplements, determined an increase of the rate n-3/n-6 PUFA serum concentration thus supporting the general trend towards an amelioration of inflammatory status. This was established in 12 out of 29 patients, on the basis of reduced active MMP-9 levels in the RRTD, RRTDI and PPMS groups), and of anthropometric parameters as well. PPMS patients were more responsive to the nutritional intervention with fish oil and lipoic acid."
let's take a closer look at that regimen...
"Dietary supplements, daily dosage, and duration of administration
Dibase Abiogen Pharma, vitamin D3 (cholecalciferol), 714 IU/day
(5000 IU, once the week, for five months) + 200 IU with a multivitamin complex (Vit M O.T.I.) (daily administration for four months).
Vit M O.T.I., multivitamin complex (including oligoelements), per day, for four months: vitamins: C (120 mg), PP (36 mg), E (20 mg), B6 (4 mg), B2 (3.2 mg), B1 (2.8 mg), B12 (2 mcg), A (1.6 mg), D3 (5 mcg); biotin (0.3 mg), pantothenic acid (12 mg), folic acid (0.4 mg); oligoelements: zinc (30 mg), iron (28 mg), copper (3 mg), manganese (3 mg), selenium (120 mcg), fluorine (3 mg), iodine (0.3 mg)."
so low daily d3 and no magnesium at all, interesting design choices :S ...