Multiple Sclerosis not disease of immune system?

[MSUK]

An article to be published Friday (Dec. 23) in the December 2011 issue of The Quarterly Review of Biology argues that multiple sclerosis, long viewed as primarily an autoimmune disease, is not actually a disease of the immune system.

Dr. Angelique Corthals, a forensic anthropologist and professor at the John Jay College of Criminal Justice in New York, suggests instead that MS is caused by faulty lipid metabolism, in many ways more similar to coronary atherosclerosis (hardening of the arteries) than to other autoimmune diseases.

Framing MS as a metabolic disorder helps to explain many puzzling aspects of the disease, particularly why it strikes women more than men and why cases are on the rise worldwide, Corthals says. She believes this new framework could help guide researchers toward new treatments and ultimately a cure for the disease....Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/3267

[HarryZ]

And we thought that Zamboni's work shook up the world of MS!!! I can imagine the fall out that Dr. Corthals is going to receive.


Harry

[CVfactor]

This is great news for those people who see a marine biologist to treat their high blood pressure! Anything is possible when you suspend logic.

[HarryZ]

This is great news for those people who see a marine biologist to treat their high blood pressure! Anything is possible when you suspend logic.

Perhaps you should send him a personal note and tell him that you think he is a quack.

[CVfactor]

The term "quack" usually refers to medical doctors. It does not apply anymore in the age of the internet where anyone can be an expert on any subject.

[HarryZ]

The term "quack" usually refers to medical doctors. It does not apply anymore in the age of the internet where anyone can be an expert on any subject.

In that case I'm waiting to hear back from you what kind of reply Corthals gives you when you express your opinion to him.

[CVfactor]

Since she is a professor of criminal justice maybe she is onto something here. It could be that only criminals or people with relatives who are criminals get ms. Youre right, I should contact her to investigate my thoery. Hold on folks, the cure is near.

[jv]

Her theory is, shortly: oxidized LDL forms plaques, the accumulation of plaque triggers an immune response, which leads to scarring.
She made a few mistakes, high cholesterol is not a risk factor for MS, animal fat consumption in US is on the decline since the 50's, yet MS is on the rise.

[cheerleader]

Fact check time...
you guys always crack me up

Dr. Angelique Cortais is a woman, and more than a forensics specialist.

I am a scientist focused on the past, present, and future of autoimmune and infectious diseases. My research program uses proteomics, DNA-based ecology and epidemiology to model the environmental and genetic risks of diseases.

Her theory -

Corthals believes that the primary cause of MS can be traced to transcription factors in cell nuclei that control the uptake, breakdown, and release of lipids (fats and similar compounds) throughout the body. Disruption of these proteins, known as peroxisome proliferator-activated receptors (PPARs), causes a toxic byproduct of “bad” cholesterol called oxidized LDL to form plaques on the affected tissue. The accumulation of plaque in turn triggers an immune response, which ultimately leads to scarring. This is essentially the same mechanism involved in atherosclerosis, in which PPAR failure causes plaque accumulation, immune response, and scarring in coronary arteries.

No. It's not new. Drs. Swank, Fog, Putnam and James had similar suppositions. What I like is that she's coming out swinging.
Personally, although I'm not a doc or researcher, I find it intriguing, and it certainly fits in with the vascular research happening now. I put her in touch with the ISNVD. Hopefully there can be some cross-over in her research to that of Dr. Cooke, the endothelial researcher at Stanford I contacted in '08, and Dr. Alexander, the endothelial researcher at LSU. Blood matters. The endothelium matters. How it all fits together is being clarified.
cheer

[CVfactor]

You crack me up. From Dr. Dake:

The present consensual view of interventional-ists and hopeful patients is resigned to the conclusion that treatment of CCSVI is not a cure for MS. Debates rage over what roles, if any, CCSVI may play in conjunction with the genesis, pro-gression and symptoms associated with MS, but even the most evangelical CCSVI advocates understand that relief of extracranial venous obstruction will not magically re-myelinate compromised axons or reverse existing plaques.

I guess he is wrong.

[cheerleader]

CV-I agree with my husband's doctor.
There is no cure for stroke. There is only stroke prevention and rehabilitation.
Jeff continues to have no new lesions, no relapses and continued symtom relief, now almost 3 years after venoplasty.
And his gray matter loss has reversed.
happy holidays--
cheer

[HarryZ]

Jeff continues to have no new lesions, no relapses and continued symtom relief, now almost 3 years after venoplasty.
And his gray matter loss has reversed.

Now Cheer,

According to CV's opinions, your husband has to be imagining the results he is getting from venoplasty because MS is an autoimmune disease and any other plausible explanation for these new ideas are obviously the work of charlatans. When are you going to realize this?

Harry

[CVfactor]

Not just me but also his doctor. Harry I think you may have a reading dissabilty. This may be the reason you are mixed up all the time.

[scorpions]

CV-I agree with my husband's doctor.
There is no cure for stroke. There is only stroke prevention and rehabilitation.
Jeff continues to have no new lesions, no relapses and continued symtom relief, now almost 3 years after venoplasty.
And his gray matter loss has reversed.
happy holidays--
cheer

Cheer I believe I have heard about your husbands improvements/reversal of gray matter loss before and once again I congratulate both he and you on this wonderful gift. It has been almost 4 years and I have had no new symptoms(in fact some have diminished) and no new relapses and I have not had venoplasty or taken any medications. I can not attribute this lack of MS activity to anything specific so I chalk it up to the luck of the draw(so far). Just a reminder HarryZ that not all "mainstream" researchers are devils and every individual with a fringe idea is not an angel. Hope everyone has a nice Christmas and Happy New Year!

[HarryZ]

Not just me but also his doctor. Harry I think you may have a reading dissabilty. This may be the reason you are mixed up all the time.

CV......you've missed the whole point...sigh...Harry