Stress

[melissa7]

I am recently diagnosed and still learning. I was wondering if any of you believe that stress can cause flares to happen?

[jimmylegs]

i do. stress can make you dump nutrients, and i'm all about nutrition for ms

[jackD]

Here is something for your edification. You might want to find out how all these things il-6, il-12, il-10,TNF-a and gamma interferon relate to MS progression.

jackD


Biol Res Nurs. 2011 Nov 14. [Epub ahead of print]

Psychological Stress and Cytokine Production in Multiple Sclerosis: Correlation With Disease Symptomatology.
Sorenson M, Janusek L, Mathews H.

Department of Nursing, DePaul University, Chicago, IL, USA.

Objective: Psychological variables such as perceived stress appear to play a role in symptom onset or disease exacerbation in multiple sclerosis (MS). The authors sought to determine if perceived stress is indeed associated with the expression of pro-inflammatory cytokines and disease symptoms in individuals with MS. To do so, the authors examined the relationships among disease symptomatology, perceived stress, and cytokine production from peripheral blood mononuclear cells in 42 outpatients with MS and 36 normative controls. Method: The authors drew peripheral blood from all subjects prior to the completion of a series of psychological instruments. The authors measured stress using the Perceived Stress scale and negative mood with the Profile of Mood States. Disease symptoms were measured using the Multiple Sclerosis Symptom Checklist. Cytokine production was induced separately by lipopolysaccharide and a combination of phytohemagglutinin and phorbol-12-myristate-13-acetate.

Results: In MS subjects, the induced production of interleukin (IL)-6 and IL-10 positively correlated with psychological stress, mood disturbance, and disease symptomatology.

n contrast, psychological stress in control subjects significantly correlated with level of tumor necrosis factor-alpha (TNF-α), and mood disturbance correlated with levels of TNF-α and interferon-gamma. As well, compared to controls, MS subjects exhibited a significant fourfold increase in the production of IL-12.

Conclusion: There is, in those with MS, a pattern of IL-6 and IL-10 production that correlates significantly with perceived stress and disease symptomatology.

PMID: 22084401 [PubMed - as supplied by publisher]


HINT ... See below for bad actors in MS

http://home.ix.netcom.com/~jdalton/ms-two-stages.pdf
.
A picture is worth a 1000 words. Here is a BIG picture.
.

A picture is worth a 1000 words. Here is a BIG picture.

[melissa7]

@JackD....can you explain that to me in layman's terms. I am not familar with those medical terms. But I'm thinking the answer to my question is yes.

Thanks.

[jackD]

Interferon Gamma increase is BAD for MSers. Il-12 increases is BAD for MSers.

See above picture and abstract below.

jackD


Brain.

2006 May;129(Pt 5):1306-18. Epub 2006 Feb 27.

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress.

Lin W, Kemper A, Dupree JL, Harding HP, Ron D, Popko B.
SourceDepartment of Neurology, Jack Miller Center for Peripheral Neuropathy, University of Chicago, Chicago, IL 60637, USA.

Abstract
Interferon-gamma (IFN-gamma) is believed to play a deleterious role in the immune-mediated demyelinating disorder multiple sclerosis. Here we have exploited transgenic mice that ectopically express IFN-gamma in a temporally controlled manner in the CNS to specifically study its effects on remyelination in the cuprizone-induced demyelination model and in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. CNS delivery of IFN-gamma severely suppressed remyelination in both models and impaired the clinical recovery of the mice experiencing EAE. These observations correlated with a dramatic reduction of oligodendroglial repopulation in the demyelinated lesions. Moreover, we found that in cuprizone-treated mice the detrimental actions of IFN-gamma were associated with endoplasmic reticulum (ER) stress in remyelinating oligodendrocytes. Compared with a wild-type genetic background, the presence of IFN-gamma in mice heterozygous for a loss of function mutation in the pancreatic ER kinase (PERK), a kinase that responds specifically to ER stress, further reduced the percentage of remyelinated axons and oligodendrocyte numbers in cuprizone-induced demyelinated lesions. Thus, these data suggest that IFN-gamma is capable of inhibiting remyelination in demyelinated lesions and that ER stress modulates the response of remyelinating oligodendrocytes to this cytokine.

PMID:16504972[PubMed - indexed for MEDLINE]

[lyndacarol]

Here is something for your edification. You might want to find out how all these things il-6, il-12, il-10,TNF-a and gamma interferon relate to MS progression.

jackD


Biol Res Nurs. 2011 Nov 14. [Epub ahead of print]

Psychological Stress and Cytokine Production in Multiple Sclerosis: Correlation With Disease Symptomatology.
Sorenson M, Janusek L, Mathews H.

Department of Nursing, DePaul University, Chicago, IL, USA.

Objective: Psychological variables such as perceived stress appear to play a role in symptom onset or disease exacerbation in multiple sclerosis (MS). The authors sought to determine if perceived stress is indeed associated with the expression of pro-inflammatory cytokines and disease symptoms in individuals with MS. To do so, the authors examined the relationships among disease symptomatology, perceived stress, and cytokine production from peripheral blood mononuclear cells in 42 outpatients with MS and 36 normative controls. Method: The authors drew peripheral blood from all subjects prior to the completion of a series of psychological instruments. The authors measured stress using the Perceived Stress scale and negative mood with the Profile of Mood States. Disease symptoms were measured using the Multiple Sclerosis Symptom Checklist. Cytokine production was induced separately by lipopolysaccharide and a combination of phytohemagglutinin and phorbol-12-myristate-13-acetate.

Results: In MS subjects, the induced production of interleukin (IL)-6 and IL-10 positively correlated with psychological stress, mood disturbance, and disease symptomatology.

n contrast, psychological stress in control subjects significantly correlated with level of tumor necrosis factor-alpha (TNF-α), and mood disturbance correlated with levels of TNF-α and interferon-gamma. As well, compared to controls, MS subjects exhibited a significant fourfold increase in the production of IL-12.

Conclusion: There is, in those with MS, a pattern of IL-6 and IL-10 production that correlates significantly with perceived stress and disease symptomatology.

PMID: 22084401 [PubMed - as supplied by publisher]

From The Belly Fat Cure by Jorge Cruise, page 3:

Researchers at the Washington University School of Medicine in St. Louis confirmed that visceral belly fat (the kind that wraps around your internal organs, not the kind you can pinch) releases inflammatory molecules called interleukin-6; higher levels of these molecules are connected to increased levels of C-reactive protein, which in turn, is connected to chronic inflammation. Scientists in London substantiated this link by declaring visceral fat a "key promoter of… chronic inflammation." Even though inflammation starts out as our bodies way to protect itself, when it becomes chronic, its causes cellular damage that ages our tissues and organs and can eventually lead to arterial stiffness and heart disease.

Remember that insulin is necessary for fat storage.

[shaight]

I am recently diagnosed and still learning. I was wondering if any of you believe that stress can cause flares to happen?

i think it is a hard thing to nail down in a study. stress comes and goes throughout the day or week or month. although, i believe in my heart that it does play a role. then again, i think stress is bad for everyone whether you have MS or not.

[Thomas]

Stress definitely causes a flareup of my symptoms. Two studies on the relationship between stress and MS:

"The relationship between acute stress and aggravation of quiet or asymptomatic MS is well established by medical literature especially that which has come out since the year 2000.":
http://www.braininjury.com/multiplesclerosis.shtml

"Stressful events were associated with increased exacerbations in relapsing-remitting multiple sclerosis.":
http://www.bmj.com/content/327/7416/646 ... d=14500435

[shaight]

^ thank you for posting those links.

[Thomas]

You're welcome.