Jimmylegs...too much vitamin d = ouch?

[jimmylegs]

true.. 5 thousand mg, 2 million IU, tomayto tomahto

b6 should help. 50mgs will be okay a couple times a day for say a week. after that you could drop back to 50mg a day for maybe another three weeks. and then, maybe a retest to see if there has been an improvement in the mag absorption.

daily b6 intakes over 100mg and over the long term have been associated with negative side effects - that assessment was likely done on meat-eaters though.

so, I shouldn't think there is any reason to be too worried about 100mg for a few days running or daily 50mg thereafter - especially if you're not eating the animal foods with 100% b6 absorption, and not tracking intakes of the fibre/glucoside-containing veg foods that deplete b6.

in the long longer term, you could potentially experiment with even lower doses. but, figuring out if it helps with the mag could be good enough for the short term

[jimmylegs]

I have similar situation as you, I have vit D level at the low end of normal range ~40ng and calcium slightly over the limit.

sample normal range for vit d3: "The normal range is 30.0 to 74.0 nanograms per milliliter (ng/mL)."
FYI Leonardo - 40 ng/mL * 2.496 comes out to ~100 nmol/L which I would call the low end of optimal.
yes, could stand to go higher, but no specific worries about being low.

at least it's not 40 nmol/L, that would be a whole other story..!

[Scott1]

Hi Anonymoose,

Have you been checked for mycoplasmas and similar infections. There is a connection with iron deficiencies.

See- http://jid.oxfordjournals.org/content/1 ... ull#ref-17

These guys are pretty impressive

"We reported in 1984 that cytotoxic activated macrophages cause a major perturbation of iron homeostasis in neoplastic cells [17]. Viable target cells lose a significant portion of their intracellular iron (>70%). Concurrently, a characteristic pattern of activated macrophage-induced metabolic inhibition is observed, including inhibition of both DNA replication and mitochondrial respiration."

[jimmylegs]

I would think the dietary deficit would be the most significant contributor here, followed by gender considerations..

Low iron status and enhanced insulin sensitivity in lacto-ovo vegetarians
http://journals.cambridge.org/productio ... tid=891732

Hematological parameters, ferritin and vitamin B12 in vegetarians.
http://www.ncbi.nlm.nih.gov/pubmed/10410487

Nutrient intake and haematological status of vegetarians and age-sex matched omnivores.
http://europepmc.org/abstract/MED/79569 ... ApWqViNF.2

[Anonymoose]

Oh scott1...You are always looking for the obscure! I was 100% vegan from 2005 to 2010 and then only slightly not vegan. It's likely a dietary issue combined with the effects of rituxan that caused my iron crash. But if I continue to have issues with iron and can't back off this level of supplementation, I will go ahunting for mycoplasma and other critters. Do antibiotics affect them? I did do a three month stint on CAP...and felt worse for my efforts.

Jimmylegs...I feel amazing. I took a 50mg p5p b6 with 200mg mag this afternoon. So far so good. Yippee! You da (wo) man!

[jimmylegs]

glad you are feeling well!

[Scott1]

Hi Anonymoose,

Yep, some antibiotics affect them but the courses need to be super long term. 3 months is like a Sunday afternoon when it comes to clearing Mycoplasma, Rickettsia etc. A short course would stir them up and probably you would feel worse. Essentially they are competing with you for nourishment. You would expect a bit of herxing.

You would only know if they are there, if you're tested for them.

Now the rituxan is finished what tests does your doctor intend to do or was he just guided by you?

Regards

[Anonymoose]

Yikes! Let's just hope I don't have those mycoplasma. Sounds nightmarish.

I don't know what tests my neuro has planned for the future (other than csf and MRI). As for me "just guide (ing)" him, I assume his education and experience guide him as he tries to decide whether or not and how he will go about honoring his patient's wishes.

[jimmylegs]

interesting connections here

SERUM ZINC AND COPPER CONCENTRATIONS IN RAMS EXPERIMENTALLY INFECTED BY MYCOPLASMA AGALACTIAE (2005)
http://www.slovetres.si/files/pdf/volum ... p31-36.pdf.
"...before and after inoculation copper level showed a non-significant decrease whilst zinc level had a significant decrease (p<0.05). ... In conclusion it was suggested that, zinc deficiency played an important role in the formation of disease symptoms."

Zinc-Altered Immune Function and Cytokine Production (2000)
http://jn.nutrition.org/content/130/5/1407S.short
"Zinc inhibits only superantigens binding to the MHC class-II β-chain, like Staphylococcus aureus enterotoxins (se) A, D and E and the Mycoplasma arthritidis superantigen"

Divergent Effects of Zinc on Different Bacterial Pathogenic Agents (1995)
http://jid.oxfordjournals.org/content/171/2/486.short
"...zinc levels specifically down-regulated monocyte activation caused by some superantigens, staphylococcal enterotoxin A and E and Mycoplasma arthritidis-derived superantigen, but not toxic shock syndrome toxin-to"

Zinc adequacy of meals prepared for a Title VII nutrition program in Lubbock, Texas (2012)
http://repositories.tdl.org/tdl-ir/handle/2346/14390
"Beisel et al. (1974) reported that serum zinc and iron concentrations were rapidly depressed in most bacterial, viral and rickettsial infections. ..."

Serum levels of copper, selenium and manganese in forestry workers testing IgG positive for Brucella, Borrelia, and Rickettsia
http://tih.sagepub.com/content/early/20 ... 0.abstract
"Rickettsia showed higher levels of all three tested metals. The concentration of the examined metals did not show statistically significant difference between IgG-positive subjects versus subjects with Borrelia compared to controls. These data could confirm the role of both Cu and Se in the regulation of immune response."

would be nice to see the copper zinc ratio in that last one.

[Scott1]

There's a whole lot of similar things. We have all heard of C. pneumoniae but there's also Mycoplasma pneumoniae, a string of rickettsia, prions,etc.
If you can't maintain adequate levels something might be scavenging. Only tests can tell.
I've had C. pneumoniae and I do have Mycoplasma pneumoniae but as I feel quite well I'm not having that one treated yet.

[Anonymoose]

Just a quickie...dropping the b6. At only 50mg/day it's giving me headaches.

Edit: Oops. Forgot to mention last dose of magnesium is making me sleepy (doesn't that mean you have enough?) so I'm going down to 400mg/day. Unless that's wrong.

[jimmylegs]

hmm that doesn't make sense to me! anything else in the routine different? what's the full regimen (including food) been over the last few days? as for the last dose of mag, yep it can be relaxing - take it at bedtime and no problem 400mg per day sounds fine for maintenance of current levels. but it depends how it balances against the calcium.

[Anonymoose]

Regimen was:
530am 500mg valtrex
630am 25mg iron
730am breakfast, 1/3 dose bone maker
930am 200 or 400mg mag w/50mg b6
Lunch
???pm 200mg mag if didn't do 400mg earlier
Dinner
700pm 200mg mag (sat night first b6 dose that took me from feeling awesome to tired and somehow off)
900pm 50mg iron

Diet...lol! You had to ask me about *those* days?! Well Saturday started with an egg, biscuit, and mushroom/onion/green pepper potato hash. Lunch was chocolate at the movies. Dinner was French toast. What can I say? I had cravings! Sunday...doh! Bagel with cheddar for breakfast. No lunch. Uh...clam spaghetti for dinner. Usually I would have had a dark green salad with that but I was afraid it would interfere with iron absorption and I didn't want to eat those poor clams for no good reason! Yesterday (took am b6), egg on sandwich thin breakfast, pear for lunch, faux turkey, baked potato and broccoli for dinner. I know. I knoooow. Too much junk and not enough fruits and veggies. But the headaches started with the b6 and stuck around. So far, no b6 and no headache today...still haven't had breakfast or bone maker though.

The calcium:mag right now is 400:400 (doubling the bone maker for more d and going down to one mag pill a day.)

I'm chomping at the bit to get labs done again because it seems like things have shifted somehow but it's too soon. <pout>

[jimmylegs]

lol you and gluten, sitting in a tree! I will look at this in more detail later

[Anonymoose]

Oooo! I forgot! Yesterday I had one of those Amys scrambled tofu thingies for lunch...with salsa and my hot lover, whole grain toast. Pllllllltttt! Pear must have been a snack.

Do you seriously need to look at that in more detail?! Even I know it's a jacked up mess!