VitaminD promotes vascular regeneration

[PointsNorth]

http://www.ncbi.nlm.nih.gov/pubmed/25015343

[THX1138]

Considering the very negative results I had from taking 5k to 10k of vitamin D/hormone D for over a year and the problems others have had, I feel the need to highlight part of the study:

Abstract
BACKGROUND:
-Vitamin D deficiency in humans is frequent and has been associated with inflammation. The role of the active hormone, 1,25-dihydroxy-vitamin D3 (1,25-VitD3) in the cardiovascular system is controversial. High doses induce vascular calcification; vitamin D3 deficiency, however, has been linked to cardiovascular disease as the hormone has anti-inflammatory properties. We therefore hypothesized that 1,25-VitD3 promotes regeneration after vascular injury

http://www.ncbi.nlm.nih.gov/pubmed/25015343

[muse]

Magnesium deficiency causes "Vitamin" D resistance - That is BASIC knowledge in Biochemistry!!! And sunshine is NOT = “Vitamin” D! Sunshine CONVERTS Hormone D in its active form called Calcitriol and for that reason it needs ENOUGH!! Cholesterol (layer under the skin), which gets activated by the sun to do this job and our body knows EXACTLY HOW MUCH it has to absorb to produce enough BUT NOT TO MUCH active “D” to stay healthy!!!
The “Vitamin” D, those idiots/Big Pharma are selling to the public is “synthetically derived sheep-skin oil exposed to UV-B light” (same as rat poison!!! have a look: http://thepeopleschemist.com/stinky-sulfur-award.../) and the body has to take it whether it needs it or not. Please read my notes regarding this topic ‘Hormone D, Cholesterol, Calcium & Magnesium Connection’: or and for further information about basics in Biochemistry: “Magnesium regulates Calcium... !”

For advice regarding nutrition and/or mineral/vitamin deficiency I wouldn't ask neither Dr Zamboni nor Dr Schelling et al and I wouldn't ask my dentist or gynecologist for the same reason either. That isn't any offense against those brilliant minds but common sense!!

Arne ....totally sick of this "D"-brain wash

[cheerleader]

We've known for awhile that low vitamin D levels are related to endothelial dysfunction. Which was why I included it in the Endothelial Health program all those years ago. http://ccsvi.org/index.php/helping-myse ... ial-health

What this study was showing was that by supplementing 4,000 IU of vitamin D--the endothelial cells in humans functioned better. That's all. Supplementing 4,000 IU of D3 improved endothelial health in humans.

Endothelial dysfunction exists. It causes blood vessels to function sub-optimally. There is much that can be do to improve blood vessels. Mineral balance is essential...Arne is right to stress Mg, Jimmy stresses zinc. Vitamin D, when balanced in the human body (via UV rays or a moderate oral supplementation) really does help.


I'm just thankful that finally the CCSVI community is seriously studying the endothelium. And as a vascular doctor, Dr. Zamboni has the tools and skills to do this.
Dr. Zamboni recently discovered that the veins and valves of pwCCSVI do not have ANY endothelial cells. http://www.ncbi.nlm.nih.gov/pubmed/24972760

Endothelial cell death is pretty serious dysfunction.

cheer

[jimmylegs]

Jimmy stresses zinc.

among other things

[muse]

We are being flooded with a lot of stuff, which is toxic to the body f.e. synthetically derived sheep-skin oil, inorganic Copper or tones of Ascorbic Acid disguised as “Vitamin” C and all of this crap creates dynamics that lead to simultaneous problems like Copper toxicity (very difficult & confusing!), Zinc or Iron deficiency/excess. BUT Magnesium is a very straight line regarding health, disease & death and it is the ONLY mineral that causes Hormone-D and/or Insulin resistance. Neither Zinc nor Iron etc. etc. are able to do this to our bodies if we are deficient in it.

Arne

[Cece]

Dr. Zamboni recently discovered that the veins and valves of pwCCSVI do not have ANY endothelial cells. http://www.ncbi.nlm.nih.gov/pubmed/24972760

The internal jugular veins' wall showed a significant derangement of the endothelial layer as compared to controls. Surprisingly, no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina.

I am trying to interpret this but I read it as being only the valves themselves ("the defective cusps") that had zero endothelial cells, while the internal jugular vein walls had "significant derangement of the endothelial layer." The endothelium is deranged but present, in the walls, and not present, in the valves? This would be important, because a deranged enthothelium in the IJV walls might heal once the flow is normalized, but entirely absent endothelium would not recover -- or would it?

[MarkW]

Hello Joan,
Exactly why pwMS who have vitD3 blood levels 125-150 nmol/L do better than pwMS with vitD3 below 75nmol/L could quite possibly be linked to endothelial health. MS is truly a multi-factorial disease, so let's help our bodies any way we can.
For the record, using sunshine to increase vitD3 levels is my recommendation. However, not many pwMS are fortunate enough to live in California, so we use natural fish body oil to increase our vitD3 blood levels. (Its the blood level not the dose taken that is important).
Kind regards,
Mark
PS Its a grey August day here in Oxford, no UV rays today.

We've known for awhile that low vitamin D levels are related to endothelial dysfunction. Which was why I included it in the Endothelial Health program all those years ago. http://ccsvi.org/index.php/helping-myse ... ial-health
What this study was showing was that by supplementing 4,000 IU of vitamin D--the endothelial cells in humans functioned better. That's all. Supplementing 4,000 IU of D3 improved endothelial health in humans.

Endothelial dysfunction exists. It causes blood vessels to function sub-optimally. There is much that can be do to improve blood vessels. Mineral balance is essential...Arne is right to stress Mg, Jimmy stresses zinc. Vitamin D, when balanced in the human body (via UV rays or a moderate oral supplementation) really does help.
I'm just thankful that finally the CCSVI community is seriously studying the endothelium. And as a vascular doctor, Dr. Zamboni has the tools and skills to do this.
Dr. Zamboni recently discovered that the veins and valves of pwCCSVI do not have ANY endothelial cells. http://www.ncbi.nlm.nih.gov/pubmed/24972760
Endothelial cell death is pretty serious dysfunction.
cheer

[PointsNorth]

Perhaps using a large pulse dose of Calcitriol followed by D3 for affected IJV/valve?

https://www.google.ca/#q=endothelial+dy ... calcitriol

[1eye]

CONCLUSION:

In vivo and in vitro activation of VDR with calcitriol improves endothelial function by normalizing the expressions of AT(1)R and radical generating and scavenging enzymes and thus preventing ROS over-production. The present findings suggest that calcitriol is effective in preserving endothelial function in hypertension.

Then why not come out and say it? "present findings suggest" is not very positive, yet, if the suggestion is true, then calcitriol is a very effective treatment for hypertension in renal malfunction. What other forms of hypertension does it treat, by its action on the endothelium?

[1eye]

Dr. Zamboni recently discovered that the veins and valves of pwCCSVI do not have ANY endothelial cells. http://www.ncbi.nlm.nih.gov/pubmed/24972760

The internal jugular veins' wall showed a significant derangement of the endothelial layer as compared to controls. Surprisingly, no endothelial cells were found in the defective cusps, and the surface of the structure is covered by a fibro-reticular lamina.

I am trying to interpret this but I read it as being only the valves themselves ("the defective cusps") that had zero endothelial cells, while the internal jugular vein walls had "significant derangement of the endothelial layer." The endothelium is deranged but present, in the walls, and not present, in the valves? This would be important, because a deranged enthothelium in the IJV walls might heal once the flow is normalized, but entirely absent endothelium would not recover -- or would it?

Would that not depend on what cause it to be missing, presumably the same thing that caused its derangement elsewhere? If calcitriol is effective in protecting endothelium from some kinds of damage, will it protect valve cusps, and perhaps help allow their endothelium to be restored in CCSVI?

[MarkW]

Perhaps using a large pulse dose of Calcitriol followed by D3 for affected IJV/valve?
https://www.google.ca/#q=endothelial+dy ... calcitriol

My understanding of Calcitriol pulse plus raising Vit D3 blood level also impacts the immune system (see Prof Hayes work posted by SqueakyCat in D3 thread). Personally I would try this if an effective pulse dosage of Calcitriol in humans was known.
Kind regards,
MarkW

[PointsNorth]

Mark,

15mcg Calcitrol was enough to strengthen my right quad muscle & eliminate clonus. spasticity was greatly reduced at 4 weeks post dosing. Was taking 10Kiu D3 daily. All improvement was lost after discontinuing D3 for 1 week. A member of our group experienced complete elimination of clonus and spasticity within 1 week of his dosing and reported his walking was greatly improved.

PN

[1eye]

I think my right quad muscle has responded very well to 2 days' riding on my recumbent tricycle (yesterday was ~10k). My clonus and spasticity comes and goes, without D3 or Calcitriol. It also tends to respond to small occasional doses of baclofen.

I intend to try a few of these things, and any report of improved walking is welcome to me. My whole left side is weak. I am dizzy when tired.

All improvement was lost after discontinuing D3 for 1 week.

I am wary of any treatment whose benefits go away after such a short time. I am not likely to take Calcitriol or megadoses of D3, if it is not much less temporary than baclofen in its effects. The last thing I need is another symptomatic treatment that requires a lifetime prescription. D3, if it were all that was needed, is at least cheap.

I believe what you say, it's just a lot more information is needed.

[PointsNorth]

1eye,

15mcg Calcitriol was enough to trigger positive changes re: clonus, muscle strengthening (one) and reduction in spasticity. A trial will hopefully be done to measure changes to the immune profile. If I were you I'd try a 15mcg pulse of Cal while on 10kiu D. I would probably try 20mcg. I could Skype you if your're interested.

Best, PN