Could anatabine citrate be a used as a MS therapy?

[MSUK]

Drug development company Rock Creek Pharmaceuticals has announced a new clinical trial application with the Medicines Healthcare Products Regulatory Agency (MHRA) has been approved. The company is set to proceed with a Phase I study of Anatabine Citrate, a chemical that is found naturally in aubergine, potatoes, green tomatoes and other members of the Solanaceae family of plants, as well as in tobacco and tobacco smoke. The chemical is known for its anti-inflammatory properties unique from other anti-inflammatory drugs on the market, and may benefit patients with multiple sclerosis (MS)..... Read More - http://www.ms-uk.org/emergingtherapies

[lyndacarol]

Drug development company Rock Creek Pharmaceuticals has announced a new clinical trial application with the Medicines Healthcare Products Regulatory Agency (MHRA) has been approved. The company is set to proceed with a Phase I study of Anatabine Citrate, a chemical that is found naturally in aubergine, potatoes, green tomatoes and other members of the Solanaceae family of plants, as well as in tobacco and tobacco smoke. The chemical is known for its anti-inflammatory properties unique from other anti-inflammatory drugs on the market, and may benefit patients with multiple sclerosis (MS)..... Read More - http://www.ms-uk.org/emergingtherapies

In this recent post by NHE (http://www.thisisms.com/forum/post232228.html#p232228) there is mention of the nightshades, a family of foods which includes eggplant (a.k.a. aubergine), potatoes, tomatoes, peppers – the very ones containing the chemical Anatabine Citrate soon to be in Phase I study for MS therapy (!), anticholinergic drugs, and possible links to dementia.

http://www.peoplespharmacy.com/2015/01/ ... -dementia/

Modern-Day Anticholinergics
Most physicians are offered a few hours of training about anticholinergic drugs (at best). They are taught about belladonna, aka deadly nightshade. (The drugs atropine, hyoscyamine and scopolamine were derived from the plant Atropa belladonna.) Such medications have been used to treat diarrhea and what was once called “spastic colon.” The combination of atropine and diphenoxylate (Lomotil) remains popular for diarrhea.

Scopolamine (Transderm Scop) is still prescribed for motion sickness, and ophthalmologists and optometrists may use atropine drops to dilate the pupils during an eye exam. Doctors also employ other anticholinergic drugs such as ipratropium (Atrovent) and tiotropium (Spiriva) for asthma. Anticholinergics such as fesoterodine (Toviaz), oxybutynin (Ditropan) and tolteradine (Detrol) are frequently utilized to control the symptoms of overactive bladder.

A friend with MS has been told to avoid the nightshades. Could the chemical anatabine citrate be something to avoid rather than embrace? Could it have the anticholinergic properties that lead to dementia?