2015 ISNVD abstracts online now!

[cheerleader]

All available in Veins and Lymphatics publication--
http://www.pagepressjournals.org/index. ... /view/5398

cheer

[Rogan]

What an amazing group of scientists. I'm only half way through this but some of the work being presented at the ISNVD will change the future of neurodegenerative diseases for ever. As an example the first abstract from the Dutch Scientist Mat Daemen.

"Recent data indicate that autoregulation of cerebral flow cannot always protect the brain from hypoperfusion when cardiac output is reduced or atherosclerosis is prominent"

and

"we are testing the hypothesis that impaired hemodyamic status of both heart and brain is an important and potentially reversible cause of vascular cognitive impairment offering promising opportunities for treatment"

and

"while mechanistic studies are being performed in animal studies"

I assume this angioplasty or veinoplasty.

Finally someone following up on the ground breaking autopsy studies you have posted on CCSVI Alliance.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817283/

A google image search of Alzheimer's Circle of Willis is alarming

https://www.google.com/search?q=alzheim ... 80&bih=713

Hopefully in the future a brave surgeon will figure out how to clear these out too.

Thank you for all of the information you post.

[cheerleader]

Rogan--glad you are reading through all the abstracts! Agree, there were some wonderful presentations this year, especially on the heart brain connection and the impact of endothelial dysfunction on MS.

I wrote up a layperson's guide to the abstracts on my blog:
http://ccsviinms.blogspot.com/2015/03/2 ... racts.html

You might also enjoy some of the new research into (g)lymphatic vessels discovered in the brain, and the reversal of a 70 year theory of the brain's immune privilege.
http://ccsviinms.blogspot.com/2015/06/r ... books.html

It's a very exciting time in MS research, and the ISVND is leading the charge in this paradigm shift. The heart and brain are connected and the lymph system and immune cells run throughout the body.
cheer

[Rogan]

Thanks Cheerleader for a link to this blog post.

I had somehow missed that one, I try to read all of your posts.

This is incredible to quote you wrote:

Clinical Applications of Venous Treatment
Dr. Michael Dake, Stanford University
Dr. Dake, last year's ISNVD president and a founding member, will be presenting on the contributions of 2014 studies which have enhanced understanding of how endovascular and open surgical treatment of venous abnormalities has affected patients with MS, Alzheimer's disease, Parkinson's, POTS and other pathologies.

Am I reading this right? Stanford is surgically treating Alzheimer's and Parkinson patients. If so the future may be here sooner than I thought. What a powerful group ISNVD.

When I compare their varied research to some of the drug studies happening at other Neurological Research Labs there really is no comparison.

This photo is comparing healthy Circle of Willis's with the clogged Circle of Willis's from folks who had Alzheimer's




Here is a photo comparing an Alzheimer brain to a healthy brain.



When I read well funded prominent scientists are trying to come up with a monoclonal antibody drug to combat this, or a drug to clear the amyloid plaques, or a genetic study, it just seems like a drop in the bucket. It feels like they are using the wrong tool to address the symptoms not the root cause. Its seems like a waste of time.

A brain surgeon needs to get in there and clean it up. The brain is clearly wasting away, it's starved of something.

Reading your abstract summaries gives me hope that ISNVD members are going to figure this out differently.
Thank you for spreading all of this new information!

[cheerleader]

I agree, it is all exciting, and happening today, Rogan!
But we do not need a surgeon to clean anything up inside the brain, we just need the lymphatic and venous clearance route to be sufficient, so that the brain can move lymph, CSF and blood.
The real hope is in understanding how the brain cleanses itself, via the newly discovered (g)lymphatic system. I visited with the discoverer of this process, Dr. Maiken Nedergaard, in her lab. She has discovered how sleep allows for the cleansing of the brain, removing proteins and metabolite build up in Alzheimer's and other diseases of neurodegeneration.
http://ccsviinms.blogspot.com/2015/04/g ... gaard.html

And the discovery of the lymphatic vessels in the brain is providing more answers.
http://ccsviinms.blogspot.com/2015/06/r ... books.html

exciting times. Dr. Dake, the IR who treated my husband in 2009, is continuing to speak on how the venous stenting procedure my husband and others had, might improves cerebral circulation and allow for this cleansing. Next ISNVD meeting in NYC in 2016 will be pretty amazing.
cheer

[Rogan]

Yes, hopefully its as simple as good sleep and a working lymph system.

But these photos sure look like arteriosclerosis of the brain.

Could I ask you a question about atherosclerosis that I believe your Endothelium Health program addresses?

Root causes of atherosclerosis still are being debated I believe. However all doctors agree smoking and a rich diet adversely effect this.

Am I correct that the Endothelium of the veins release chemicals in the blood that help your veins and arteries stay healthy and less atherosclerotic?

Is this also a benefit of following your Endothelium Health Program?

Thanks in advance.

[cheerleader]

Beta amyloid protein deposition in the brain does look like arteriosclerosis. However, unlike plaques in major arteries, it cannot be reached via angioplasty. That's why all the pharma companies have been trying, most unsuccessfully, to remove it...but it hasn't helped people with Alzheimer's heal. Why? Probably because the plaques are a symptom of a larger problem---the failure of CSF and lymph to cleanse brain tissue. This could be due to hypoperfusion or a host of other problems. But many researchers are now looking at the heart-brain connection in Alzheimer's and dementia.

I based my program on Dr. John Cooke's ground breaking research. He was the kind doctor who answered my inquiry into the vascular connection to MS, and later connected me to Dr. Dake at Stanford---he was the first cardiovascular doctor to recommend a heart healthy program to target endothelial cells, reduce oxidative stress and limit C reactive protein. And yes, nitric oxide it the chemical which maintains and moderates the health of all our vessels, blood and lymph, via endothelial health and EDRF. Increasing nitric oxide and improving the health of endothelial cells is the benefit to both our programs. I've seen Dr. Cooke a few times over the years. He's in Houston now, creating endothelial cells out of fibroblasts, for future implantation in vessels. He still maintains that his program is the best way to deal with the heart-brain connection, until we can replace our endothelial cells.
The Cardiovascular Cure, Dr. John Cooke's book and program, would be a good place to learn more:

[Cece]

I am so behind. Downloading and reading now.

[cheerleader]

I am so behind. Downloading and reading now.

Whatcha been doing, Cece? Living life?
Here's some more reading--
the ISNVD spring newsletter


Don't worry, there won't be a quiz....
hope all is well in your world,
cheer

[vesta]

I agree, it is all exciting, and happening today, Rogan!
But we do not need a surgeon to clean anything up inside the brain, we just need the lymphatic and venous clearance route to be sufficient, so that the brain can move lymph, CSF and blood.
The real hope is in understanding how the brain cleanses itself, via the newly discovered (g)lymphatic system. I visited with the discoverer of this process, Dr. Maiken Nedergaard, in her lab. She has discovered how sleep allows for the cleansing of the brain, removing proteins and metabolite build up in Alzheimer's and other diseases of neurodegeneration.
http://ccsviinms.blogspot.com/2015/04/g ... gaard.html

And the discovery of the lymphatic vessels in the brain is providing more answers.
http://ccsviinms.blogspot.com/2015/06/r ... books.html

exciting times. Dr. Dake, the IR who treated my husband in 2009, is continuing to speak on how the venous stenting procedure my husband and others had, might improves cerebral circulation and allow for this cleansing. Next ISNVD meeting in NYC in 2016 will be pretty amazing.
cheer

Hello cheer:
Wonderful information. I've recommended your posts on my site as THE place to find current scientific research on the vascular connection to MS. The discovery of lymphatic vessels in the brain helps explain why diet is so important - to strengthen the immune system in general as well as the endothelium. Also, the fact that immune cells in the brain are there to heal, not to "attack" the brain. I believe enhancing CNS fluid flow remains the key to effective treatment. Thanks for all your work, regards, Vesta