Researchers find link between industrialised foods...

[MSUK]

Researchers find link between industrialised foods and autoimmune diseases

Israeli and German researchers claim “industrialised food additives” may raise the risk of developing autoimmune diseases, a finding that comes soon after the World Health Organization’s announcement that eating excessive amounts of processed foods raises the risk of cancer...Read more - http://www.ms-uk.org/MSnews

[1eye]

The nutritional label, that has become so ubiquitous, should taken to indicate the absence of any real food. There is no guarantee anywhere that products are going to be good for you, if habitually consumed, even if they are real food, but a nutritional label is a guarantee they will not.

[cheerleader]

It's all about the endothelium.
The additives in processed foods make tight junctions of endothelial cells to open via free radicals and NO depletion, and plasmic particles enter tissue, creating an immune response. This can happen in the gut, as well as the blood brain barrier and brain. It's not really an "autoimmune" reaction, however---it's immune cells going in to do their job, because plasmic particles have crossed the endothelial barrier. Semantics, I know....

Many autoimmune diseases result from damage to the functioning of the “tight junctions” that protect the intestinal mucosa, the researchers said. When functioning normally, tight junctions serve as a barrier against bacteria, toxins, allergens and carcinogens, protecting the immune system from them. Damage to the tight junctions (also known as “leaky gut”) leads to the development of autoimmune diseases.

The researchers found that at least seven common food additives weaken the tight-junctions – glucose (sugars), sodium (salt), fat solvents (emulsifiers), organic acids, gluten, microbial transglutaminase (a special enzyme that serves as food protein “glue”) and nanometric particles.

http://www.jpost.com/Business-and-Innov ... ses-439296

I first wrote about this issue in 2008, when I created the Endothelial Health Program.
http://ccsvi.org/index.php/helping-myse ... ial-health
it's real,
cheer

[Leonard]

gut dysfunction will weaken epigenetics.
the HERV will activite with herpes.
this causes the scourge of autoimmunity.

[cheerleader]

Here's the complete article on the research. Worth a read. http://www.jpost.com/Business-and-Innov ... ses-439296

In their study, the researchers focused on the significant increase in the use of industrial food additives aimed at improving qualities such as taste, smell, texture and shelf life, and found a “significant circumstantial connection between the increased use of processed foods and the increase in the incidence of autoimmune diseases.”

Many autoimmune diseases result from damage to the functioning of the “tight junctions” that protect the intestinal mucosa, the researchers said. When functioning normally, tight junctions serve as a barrier against bacteria, toxins, allergens and carcinogens, protecting the immune system from them. Damage to the tight junctions (also known as “leaky gut”) leads to the development of autoimmune diseases.

The researchers found that at least seven common food additives weaken the tight-junctions – glucose (sugars), sodium (salt), fat solvents (emulsifiers), organic acids, gluten, microbial transglutaminase (a special enzyme that serves as food protein “glue”) and nanometric particles.

Tight junctions refers to endothelial cells http://www.sciencedirect.com/science/ar ... 360700346X, which weaken (endothelial dysfunction) and allow plasmic particles into tissue, creating an immune system response. Don't need to go into viral theories or the epigenome to understand. It's simply a loss of the barrier that protects our gut and brain from cells that don't belong there.
cheer

[Leonard]

Thanks cheer for the links.

I beg to differ. The viral theory and epigenetics are crucial to understanding autoimmunity and B-cell growth.
This article is a must-read: http://www.ncbi.nlm.nih.gov/books/NBK6235/

Besides that, you are right that plasmic particles from a leaky gut don't exactly help and may in fact add to the problems.

I quote from the article under the first link in your last posting http://www.jpost.com/Business-and-Innov ... ses-439296
Grotto also responded to the researcher’s recommendation that patients with a family background of autoimmune diseases should consider avoiding processed foods, saying that it is “a matter of jumping to conclusions.”

There may be an influence from diet in the family background of autoimmune diseases, some families eat different from others, but I think there is more to it than just diet.
It is genetics factors that contribute here too. This is where the viral theory, the SNiPs and the HERVs and the epigenetics come around the corner.

It is fascinating what we see here being unfolded...

regards, Leo

[cheerleader]

The endothelium connects the vascular and immune systems. It allows for permeability in the blood brain barrier, the gut and all 60,000 miles of blood and lymph vessels.
The research posted was on the endothelial tight junctions lining the intestines and how they are affected by "industrialized food."
Just trying to stay on topic, discuss the research linked on this thread, Leonard.
All it takes is one single drop of blood in brain tissue to create the MS inflammatory reaction.
http://ccsviinms.blogspot.com/2015/10/a ... blood.html
cheer

[Leonard]

Thanks cheer.

With ref to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579786/ , I think it is the herpes/VZV that is causing these microbleedings.
There are some useful papers from Maria Nagel. A quick Google search found this http://www.ncbi.nlm.nih.gov/pubmed/25712420
I know there are some other good articles from Maria Nagel on the effects of herpes/VZV but I would need to search a bit more.

So now we are back in the viral dimension.

Reg, Leo

[cheerleader]

Actually, Dr. Yulin Ge, the researcher you linked, says no such thing about his 7T research into MS microbleeds.
He presented his papers at the 2014 and 2015 ISNVD conferences, and I was there. From his presentation.

The role of vascular pathology in MS was suggested long ago. Now there is accumulating evidence of a primary vascular pathogenesis in MS. In vivo studies of vascular and hemodynamic impairment in MS may provide insights into the etiology and pathophysiology of MS and offer the potential metrics for assessment of outcome of the disease.

Ge's discoveries are being replicated by Mark Haacke's team (MS MRI) in Detroit using 7T MRI, and I heard that presentation at the Canadian Neurovascular Conference. They will all be at the 2016 ISNVD conference in NYC this April, along with Ge. Venous hypertension and lack of shear stress is enough to promote endothelial dysfunction and plasmic deposition in MS. I'll report back from the ISNVD conference “How the Extracranial Venous System Influences Neurological Diseases” later this year. Here's the program: http://isnvd.org/sites/default/files/IS ... 1-2015.pdf

cheer

[Leonard]

Thanks cheer.

It seems the ISNVD is more occupied with measuring and imaging microvasculature than with the cause.

I think it can not be excluded that VZV is the underlying cause of the microbleedings.

This then - as far as the etiology is concerned - connects the matter to the HERV activation, the dysfunction of the gut microbiome..

It is the view that emerges from pg's 49, 50 and 51 of http://www.thisisms.com/forum/general-d ... 8-750.html

[cheerleader]

Again---absolutely not true, Leonard.
The ISNVD is looking at viruses as one of many endothelial disrupters.

The association between EBV infection and CCSVI has not yet been explored; however, it could be hypothesized that venous stasis in the superior saggital sinus due to extracranial outflow impairment could affect the drainage of bridging veins that pass through the subarachnoid space (near the meninges and EBV-infected B-cell follicles) and contribute to EBV activation. The venous stasis hypothesis in the SSS may contribute to understanding why so many different viruses and bacteria [3,111] have been linked to increased MS susceptibility risk over the last 50 years.

http://ccsviinms.blogspot.com/2011/08/b ... d-ebv.html

Taking into account the current epidemiological data, the autoptic findings, and the relationship between CCSVI and both hypoperfusion and cerebrospinal fluid flow, CCSVI can be inserted in the list of multiple factors involved in MS pathogenesis. Our careful data analysis may conclude that great variability in prevalence of CCSVI in MS patients can be a result of different methodologies used in venous ultrasound assessment. Finally, it has been proven that CCSVI share the three main risk factors with MS. On the other hand, smoking is the most important risk factor for endothelial cell damage, vitamin D has a protective role and Epstein-Barr virus passes the blood-brain barrier by invading the endothelial cells, therefore, epidemiologically, linking the imbalance of these three factors to MS through autoimmunity.

http://www.ncbi.nlm.nih.gov/pubmed/22971467

If you are a published researcher, please come to the next ISNVD conference, and submit your papers!
http://isnvd.org/content/abstract-submission-isnvd-2016
However, if you are like me, an interested lay person, come to the next conference--patients and advocates are invited to attend. http://isnvd.org/sites/default/files/IS ... 1-2015.pdf
register here: http://isnvd.org

The paper linked in the first post is published research about industrialized food and how it affects the tight junctions of the endothelium and autoimmune disease. Absolutely nothing about viruses in that particular published paper. Simply trying to stay on track here. If you don't think it is important research, that's fine. Some of us here do.
cheer

[Leonard]

Thanks cheer for the clarification.

I am an MS patient...

[1eye]

It seems...
I think it can not be excluded...
...connects the matter...
...view that emerges...

Could you be a little more precise and conclusive in your language? I get that you have a certain slant on MS that you would like others to share but many of us prefer something a bit more quantitative. In my increasing age I have eschewed the quantitative and much prefer to live qualitatively only, so that I am not reminded of the terror of its monotonic directional nature, and its inevitable destination. So I use many so-called "weasel-words" in things I say, and I find it has so far kept the lawyers at bay, especially when discussing things like bribery, corruption and lobbying in the drug industry.

However in science what seems, cannot be excluded, connects, and emerges, are less revealing than the numerical aspects of what we need to know.

"An eminent physicist has remarked that the future truths of Physical Science are to be looked for in the sixth place of decimals."
— A.A. Michelson

This is important, since most instruments in existence do not have that precision. If you can establish something by measurement to such precision there can be no doubt.

[Leonard]

@cheer: I think that the ISNVD should - besides EBV - look at VZV (Zoster) as the cause of the microbleedings, the endothelial inflammation, the white matter lesions etc. A bit of googling provides some very interesting papers on VZV and evasion of immunity and on VZV and MS. I think the underlying mechanism is very complicated. It causes the inflammation in RR. Immunologists know that VZV is an inflammatory virus.
Immunologists also know that EBV is an onco virus. I think the unbridled diffusion of EBV infected and immortalised B cells (our problem that causes the oxidative stress in the progressive phase) is a natural and healthy reaction of the immune system to prevent neoplasia/cancer. This article is gold: http://www.ncbi.nlm.nih.gov/books/NBK6235/ see the section on Herpesvirus—ERV Interaction: Does EBV Use a HERV for Stimulation of B Cell Growth?
The implication is that the current experiments in the Progressive MS Alliance and others to deplete the B cells by Rituximab (Ocrelizumab will be positioned as the future medication) is not without risk.
I think that we all should look at Cyclophosphamide (Endoxan) as a potential chemo drug to deplete the B cells. What is crucial here is the working mechanism by which B cells decrease. I think that Cyclophosphamide attacks the EBV/viral component and then the B cells wane, while Rituximab may work more direct on the B cells and not the virus.

@1eye: I am an MS patient, progressive, and determined to get my life back on track where possible. I am continuously scanning the horizon and keep all options open. I don't want to fall into the same trap as the medical sector, fixing the mind early on with strong preconceptions. Hence I must use words such as it seems, it can not be excluded, connects the matter, the view that emerges etc.
I am currently working on a new thesis. It takes the learnings of the pages 49, 50 and 51 of http://www.thisisms.com/forum/general-d ... 8-735.html
It will be a complete expose of what is MS, taking also account of the above considerations of VZV and EBV.
And yes, I could use some help, fresh eyes for reflection.
And it is not the sixth place of decimals where we need to find the truths, it is in the first digit of the turn over of...